Carcinoma colorettale: nuove metodiche diagnostiche.Ricerche sperimentali con spettroscopia di risonanza magnetica

This PhD thesis has been prepared with a view to the study of the application of proton magnetic resonance spectroscopy (1H MRS) in the possible non-invasive histological diagnosis of colorectal polyps and cancer. In particular, its use in staging of rectal cancer after neoadjuvant treatment (concurrent chemoradiotherapy), which is heavily deficient with traditional methods (EUS, MRI, CT and PET-CT), could allow more accurate diagnosis, overall of clinical complete responses or minimal residual disease. choices ranging from abstention widened and mutilating surgical interventions.For this purpose, the results of the use of traditional imaging methods have been first of all remembered in the literature, results which do not allow appropriate therapeutic choices for cancer, ranging from surgical abstention to extended operations. The use of the MRS on human tumors (in vivo, ex vivo and in experimental studies) was reviewed, in a more specific and detailed matter, on colorectal carcinoma. Finally in the last part of the thesis aims, methods, technological equipments and results of implemented research, made of use of 1H MRS on human surgical specimens, have been reported.