Characterization of the cardioprotective potential of discrete extracellular vesicles populations from second-trimester human amniotic fluid against Doxorubicin cardiotoxicity

Anthracyclines such as Doxorubicin (Dox) are currently broadly used in chemotherapy, representing gold-standard drugs in oncology. Nevertheless, their therapeutic use is limited by cumulative dose-dependent cardiotoxicity, which may evolve into heart failure and long-term morbidity among cancer survivors. In this context, extracellular vesicles (EVs) are emerging as promising cell-free therapeutic tools due to their ability to deliver bioactive molecules and modulate survival, redox balance, ...

Molecular Imaging Study of the Immune Response in Muscle Denervation: a High-Tech Study in Murine Models and Human Patients

Aim of the study: Muscle denervation occurs in various clinical settings, including trauma, amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease (CMT). The body’s response to periferal nervous system nerve damage involves multiple cell types, including axonal Schwann cells (SCs), terminal (perisynaptic) Schwann cells (tSCs), endothelial cells, and immune cells such as macrophages, neutrophils and T-cells. Molecular imaging has emerged as a powerful and non-invasive approach for...

Health status of aquacultured bivalves and fish: immune responses of Mytilus galloprovincialis to bacterial isolates and monitoring growth of Sparus aurata and Dicentrarchus labrax

Digital Pathology Applications in Rare and Underrepresented Thoracic Malignancies

Thoracic cancers represent a leading cause of cancer-related mortality worldwide and encompass both rare malignancies, such as thymic epithelial tumors (TETs), and highly prevalent diseases, including non–small cell lung cancer (NSCLC). Notably, even common cancers comprise multiple molecularly defined subgroups with distinct prognoses and therapeutic strategies, each of which may effectively represent a rare entity. Artificial intelligence (AI) is increasingly being integrated into clinical...

Identification of biomarkers of plaque vulnerability in carotid artery disease for the prevention of brain ischemic injury.

Carotid atherosclerosis is a leading cause of cerebrovascular events, yet risk stratification, in severe asymptomatic stenosis, remains limited. Despite advances in imaging and clinical scoring, prediction of prone to rupture plaques remains challenging. This study aimed to identify potential biomarkers of plaque vulnerability by exploring both systemic and local molecular pathways involved in inflammation, oxidative stress, structural remodelling, and neuro-immune interactions. The integrati...

Metastatic Breast-Bone Carcinoma Model Obtained through 3D Bioprinting

Breast cancer is the most frequently diagnosed cancer in the female population with about 50,000 new cases/year in Italy. Despite the significant improvement in survival rate following diagnosis of this type of cancer, there is still a clinically significant number of patients who develop distant metastases (about 12,000 new cases of metastatic breast cancer/year in Italy, with a prevalence of about 36,000 cases). Bone is the most frequent site of metastatization given the elective osteotropi...

DEVELOPMENT OF ARTIFICIAL INTELLIGENCE- ENHANCED OPTICAL BIOPSY TOOLS FOR ENDOSCOPIC EVALUATION OF LARYNGEAL TUMORS

Head and neck squamous cell carcinoma, particularly laryngeal cancer, remains a significant global health challenge. Early detection is crucial for improving survival and preserving organ function, yet endoscopic evaluation of laryngeal lesions remains highly operator-dependent and subject to inter-observer variability. Advances in artificial intelligence (AI), especially deep learning applied to medical imaging, offer the potential to enhance the accuracy, objectivity, and efficiency of endo...

The role of radiomics and delta-radiomic analysis for the prediction of prognostic and predictive factors in non-small cell lung cancer.

Gonadotoxicity of targeted therapies in young breast cancer patients and impact of carrying a germline BRCA mutation

Abstract Background: Breast cancer is the most common malignancy arising in women of reproductive age and its treatment often results in long-term sequelae and impaired quality of life (QoL). Among the possible negative consequences of anticancer therapies, treatment-induced gonadotoxicity leading to premature ovarian insufficiency (POI) represents one of the major sources of distress in this patient population. POI has a negative impact on global health and QoL of young breast cancer ...