UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION

Natural Killer (NK) cells are potent members of the innate immune system, as they are endowed with the capacity of sensing and eliminating tumor-transformed and viral infected cells by integrating a plethora of inhibitory and activating signals coming from a repertoire of germline encoded receptors whose expression is finely tuned throughout NK cell differentiation and licensing. For ontological reasons and similarities in terms of transcription factors and secreted cytokines, NK cells have b...

GUT ABSTRACTIONS. A PHILOSOPHICAL STUDY FOR THE PRESENT OF FOOD.

This dissertation investigates the role of the microbial turn within the domain of nutrition, focusing on the emergence of microbiome science and its centrality to envisioning food futures. By adopting a philosophical approach that conceptualizes philosophy as a form of negotiation, the research explores how diverse ontologies structure the categories and concepts shaping our engagement with food, including knowledge, values, norms, and practices. Specifically, the study examines two distinct...

Bio-inspired WO3 based photoanodes for Artificial Photosynthesis

Artificial photosynthesis is a long-term goal for humankind to achieve sustainable development. To realize it, PSII-inpsired Quantasome approach has been attempted, with a 2D lamellar structure formed by surrounding polyoxometalate water-oxidation catalyst (Ru4POM) with 5 perylene-bisimide (PBI) chromophores ({[PBI]5Ru4POM}n), and water channels (Tetraethylene glycol chain modified PBI, PBI-TEG), promising results for oxygenic photosynthesis have been achieved. However, the efficiency of thi...

Photo(electro)catalytic oxidation processes combining industrial pigments with semiconductors

The current energy crisis and the climate change issue call for an urgent action, in relation to the use of renewable sources of energy for the production of fuels and commodity chemicals. Among the available renewable sources, solar light is the one being abundant, free, widely distributed and inexhaustible. The energy that the Earth receives from the Sun would be in principle enough for powering the human activities for one year. Efficient capture and conversion of solar light into virtuous...

Study of Robust GNSS-based Positioning Solutions for Challenging Environments

Human-Centric Advanced Driver Assistant Systems

Symbolic Pattern Planning

Out of the single-neuron straitjacket: assembling cells to unveil dynamic coding

Understanding how billions of neurons communicate and coordinate their activity is a central pursuit of neuroscience. The concept of cell assemblies emerges as a fundamental unit of neural organization, embodying the intricate interplay of individual neurons within the complex web of the brain's circuits. The notion of cell assemblies has evolved alongside our understanding of neural dynamics and information processing, transcending epochs since its inception. Over the decades, this concept h...

Beam dynamics of high brightness beams in RF photoinjectors

ntense electron beams with high luminosity, such as those generated by radio-frequency (RF) photoinjectors, facilitate cutting-edge applications in the production of photons and the operation of high-energy physics colliders. Notable examples of advanced applications in these fields include Free Electron Lasers (FELs), Inverse Compton Scattering (ICS) sources, and high-luminosity linear electron-positron colliders. Such particle beams necessitate the simultaneous presence of high peak current...