DEVELOPMENT OF NUTRACEUTICALS AND FUNCTIONAL DRINKS CONTAINING PLANT VESICLES ISOLATED FROM CITRUS FRUITS

Measurement in quantum many-body systems: from measurement induced dynamics to quantum critical metrology

Over the past two decades, there has been a continuous and substantial increase in the scientific community's interest in quantum information. This trend is likely driven by exponential advancements in experimental platforms, which have facilitated the development of synthetic quantum matter systems, i.e., artificially engineered complex quantum systems. These advancements enable the exploration of tunable and controllable phases of matter, thereby expanding the scope of potential application...

LA LINGUA DI SCIASCIA

Mathematical Modeling of Bio-Compounds from Experimental Data

This thesis is concerned with the mathematical modeling of bioplastic compoundswith fillers of agri-food origin (brewery waste) in the context of the mechanics ofsolids. The modeling will be carried out on the basis of original experimental laboratorydata produced by using materials and equipments belonging to the Polymer,Biopolymers and Composites laboratory and to the Mechanical Treatment Prototype laboratoryof the Department of Engineering of the University of Messina in collaborationswith...

Biorisanamento di acque di falda contaminate da solventi clorurati nell'ottica dell'economia circolare

Nonequilibrium phenomena in the sine-Gordon model: From Josephson junctions and high-Tc superconductors to ultracold atoms

This thesis explores the out-of-equilibrium dynamics and collective behavior of increasingly complex sine-Gordon-type models. The sine-Gordon (SG) model is ubiquitous in solid-state systems, from extended Josephson junctions and high-temperature (high-Tc) superconductors to ultracold atoms and quantum computers being studied in Google and IBM experiments. This model is very rich because it is integrable and it supports collective soliton excitations that play a prominent role in its dynamics....

Studio del valore prognostico di CD38 nei tumori polmonari non a piccole cellule (NSCLC) con il supporto della Digital Pathology: possibile ruolo di CD38 come target di terapie mirate

BACKGROUND In NSCLC, PD-L1 Tumor Proportion Score (TPS)>1% allows Immune checkpoint inhibitor (ICI) therapies, significantly improving patients’prognosis. However, several patients develop resistance. The membrane molecule CD38, a multifunctional enzyme, has been found upregulated in NSCLC. Particularly in murine models of lung cancer, CD38 increases in tumor cells in association with resistance to PD-1/PD-L1 blockade and is found to inhibit the cytotoxic activity of CD8+ T cells in vitro....

Spectral Information Dynamics: a New Framework to Assess Multi-Order Interactions in Network Neuroscience and Physiology

Recent advances in signal processing and information theory are boosting the development of new approaches for the data-driven modelling of complex network systems. In the fields of Network Physiology and Network Neuroscience, where the signals of interest are rich of oscillatory content, the spectral representation of network systems is essential to ascribe interactions to specific oscillations with physiological meaning. This thesis introduces a coherent framework integrating several inform...

INNOVAZIONE E SOSTENIBILITÀ NELLO SVILUPPO DI ALIMENTI FUNZIONALI: STRATEGIE DI VALORIZZAZIONE DEI COMPOSTI BIOATTIVI DA SOTTOPRODOTTI DELL’INDUSTRIA AGROALIMENTARE