"Stereotipi e criminalità di genere nella giurisprudenza della Corte EDU"

Stimuli-responsive drug delivery systems based on glutathione-integrated waterborne polyurethanes for locoregional cancer therapy

Aerodynamic Optimization of H-Darrieus Vertical Axis Wind Turbine (VAWT) for Improved Efficiency under Variable Wind Conditions

Driven by the global energy shift and emissions reduction goals, wind energy has emerged as a very promising renewable energy source, distinguished by its abundant resources, established technology, and declining levelized cost of electricity. In comparison to horizontal-axis wind turbines (HAWTs), Darrieus-type vertical axis wind turbines (VAWTs) have several advantages such as no need of yaw requirements, a compact design, reduced noise levels, and simplified maintenance at ground level. Th...

Optimal Placement and Design of Multi-Unit Passive Vibration Control Systems: TMD, TLCD, and STLCD Strategies for MDOF Structures

This doctoral thesis investigates multi-unit passive vibration control systems for multi-degree-of-freedom (MDOF) structures. A multi-unit configuration consists of control units distributed across the structural system and tuned to distinct vibration modes, so that the dynamic behavior of the structure is addressed through a coordinated and spatially distributed control action.Within this framework, the multi-unit concept is examined for the mass-based Tuned Mass Damper (TMD) and for liquid-...

Clinical and biochemical predictors of response to avelumab in patients with metastatic Merkel Cell Carcinoma (MCC)

Background: Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous malignancy associated with poor prognosis. Immune checkpoint inhibitors (ICIs), including avelumab and pembrolizumab, have recently been approved as first-line treatment for metastatic MCC. Improved clinical outcomes in obese patients treated with ICIs, a phenomenon known as the “obesity paradox,” have been reported across several tumor types. However, data in metastatic MCC patients remain limited, likely due t...

Artificial Intelligence in Hemodialysis: from failures detection to patient-therapy analysis

In recent decades, technological innovation has accelerated rapidly, leading to the spread of advanced devices and technologies. This trend has also had a profound impact on the biomedical sector, where such tools are increasingly being used to optimize clinical activities, improve prevention, diagnosis, and treatment, and reduce healthcare costs. As a result, research has progressively shifted toward the development of innovative, technologically advanced, yet economically sustainable invest...

Epithelial-to-Mesenchymal Transition in Breast Cancer: A Multi-Level Study Integrating Patient Tissues, Sera, and Cellular Systems

The epithelial-to-mesenchymal transition (EMT) is a complex process pivotal in embryonic development, wound healing, and tumor progression, particularly in breast cancer (BC), a heterogeneous disease in which patients diagnosed at the same stage exhibit different clinical responses and survival outcomes. In BC progression, the EMT enhances cell survival and helps cancer cells acquire metastatic behaviors by losing epithelial phenotypic characteristics and acquiring mesenchymal traits. This th...

Electrochemical surface engineering of biomedical metal alloys

La Ri-Costruzione virtuale del prolungamento della via Toledo a Palermo (1581-1686). Analisi, Ipotesi Ricostruttiva, Fruizione

Durante il viceregno di Marco Antonio Colonna (1577- 1584) Palermo visse un’intensa fase di rinnovo urbano che culminò con l’inizio dei lavori di prolungamento della via Toledo fino al mare, da poco rettificata rispetto il più tortuoso percorso del vecchio Cassaro.Le fasi operative di tale prolungamento prevedevano importanti operazioni di sventramento dell’antico tessuto edilizio, con conseguente resezione di alcuni tra i più importanti edifici all’interno dell’area interessata dalla sezione...