Blockchain, Competitive Advantage, and Value Creation in the Agri-Food System: Empirical Evidence from Italian Firms and Consumers

Paradigmi decisionali fra bioetica e biodiritto. Una tassonomia applicata alle questioni di fine-vita.

Questa ricerca si propone di esplorare le modalità attraverso cui bioetica e diritto interagiscono per fornire risposte giustificate di fronte ai dilemmi sollevati dalle scienze della vita. Il lavoro si articola in due parti, con un progressivo passaggio dal piano teorico a quello applicativo: la Parte I si occuperà della costruzione della decisione bioetica attraverso gli strumenti del ragionamento morale e giuridico, mentre la Parte II si addentrerà nella sostanza di una controversia bioeti...

MOLECULAR MECHANISMS UNDERLYING THE ROLE AND FUNCTIONAL EFFECTS OF LONG NON CODING RNA H19 IN COLORECTAL CANCER PROGRESSION: NEW INSIGHTS INTO ITS REGULATORY ACTIVITY IN ALTERNATIVE SPLICING MODULATION

Tumor-Educated Platelets: a New Frontier in Platelet Derivatives clinical applications

Platelets, long known as key effectors of hemostasis, have progressively emerged as central actors in regenerative medicine through Non-Transfusional Use Hemocomponents (NTUHs) and Platelet Derivatives (PDs). Recently, Tumor-Educated Platelets (TEPs) have been proposed as alternative biosource for oncological liquid biopsy (LB). This Doctoral Project explored whether platelets could provide diagnostic and prognostic value in oncology, complementing their established therapeutic role, through ...

Unraveling the Relationship Between the Gut Microbiome and Colorectal Cancer: Insights from 16S rRNA Gene Sequencing

Colorectal cancer is becoming acknowledged as a condition influenced by the interplay between host factors and gut bacteria. This study examines microbiome changes linked to colorectal cancer (CRC) and their distribution throughout tumor tissue, adjacent mucosa and peripheral blood by 16S rRNA gene sequencing. Two complementary datasets were examined: a case-control analysis comparing colorectal cancer (CRC) to noninvasive colon biopsies and a paired multi-site cohort comprising tumor samples...

UNRAVELLING THE ROLE OF COLORECTAL CANCER DERIVED EXTRACELLULAR VESICLES IN DRIVING HEPATOCYTES TO ACTIVELY SHAPE HEPATIC PRE-METASTATIC NICHE: FROM IN VITRO INSIGHTS TO IN VIVO EVALUATION.

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide, with liver metastases representing the major cause of mortality. A crucial step preceding metastasis formation is the establishment of the hepatic pre-metastatic niche (h-PMN), a supportive microenvironment actively shaped by soluble factors released by the primary tumor, including CRC-derived small extracellular vesicles (CRC-sEVs). While much of the research to date has focused on the impact of CRC-sEVs...

A TETRAHYDRO-ISOQUINOLINE DERIVATIVE AS A NOVEL mGlu2/3 AGO/PAM WITH THERAPEUTIC POTENTIAL IN EXPERIMENTAL MODELS OF PARKINSONISM

Parkinson’s disease (PD) is a complex and multi-factorial neurodegenerative disorder marked by the loss of dopaminergic neurons in the nigrostriatal circuit, with the progressive development of motor and non-motor symptoms. Currently, the gold-standard within the available drug therapies are dopamine-based therapies, which only help to mitigate symptoms and are also associated with several side-effects. Indeed, no disease-modifying pharmacological treatments have been available so far. In thi...

La vita ibrida della lettrice: relazionalità, posizionalità e performatività nella trilogia auto/biografica di Sally Bayley

Questo studio analizza la trilogia auto/biografica — composta da Girl with Dove: A Life Built by Books (2018), No Boys Play Here: A Story of Shakespeare and My Family’s Missing Men (2021) e The Green Lady: A Spirit, A Story, A Place (2023) — dell'autrice britannica contemporanea Sally Bayley come esempio emblematico di innovazione e ibridazione nelle pratiche di life writing contemporaneo. L’indagine esamina la costruzione di una soggettività marginale, quella di una bambina affidata ai servi...

TACKLING CLIMATE CHANGE IMPACTS IN DEVELOPING COUNTRIES: THE CASE OF CLIMATE ADAPTATION POLICY PRACTICES IN ETHIOPIA A DYNAMIC PERFORMANCE GOVERNANCE APPROACH

Although Least Developed Countries (LDCs) have tiny contributions to GHG emissions, countries like Ethiopia remain acutely vulnerable to climate-induced shocks. Ethiopia, in response, introduced the Climate Resilient Green Economy (CRGE) Strategy in 2011, followed by successive implementation frameworks to strengthen adaptation and resilience capabilities. However, the pace and magnitude of adaptation efforts have remained insufficient to offset escalating climate and ecological risks, partic...