Synthesis of cRGD-based derivatives for tumor site-specific drug delivery

Questa tesi di dottorato si concentra sulla progettazione, sintesi e valutazione di nanosistemi basati su peptidi ciclici a base RGD (cRGD) per il drug delivery integrino mediato di molecole citotossiche ad azione antitumorale. Un risultato centrale di questo lavoro è rappresentato dallo sviluppo e dall’ottimizzazione della sintesi del 3aRGD, un peptidomimetico ciclico conformazionalmente bloccato con elevata affinità per i recettori integrinici. Particolare attenzione è stata dedicata alla p...

Guidelines for the reuse, recovery and sustainable transformation of farm and urban agriculture. Strategy development for Pavia.

The cultivation of plants and the breeding of animals enabled a rapid increase in the global population, which currently reaches eight billion. Today, large metropolises stand, consuming 75% of the Earth's resources. While, on the one hand, the population density of cities is growing faster than their physical area, which helps prevent soil consumption, on the other hand, the high demand for food threatens its availability in the coming years and the fertility of the soil (World Cities Report...

Esplorando la Nonlinearità Quantistica in Fotonica Integrata: dalla Progettazione di Dispositivi alla Fisica Fondamentale

Questa tesi studia i processi di ottica quantistica non lineare in piattaforme fotoniche integrate, con particolare attenzione alla generazione di coppie di fotoni in strutture risonanti. Partendo dal quadro teorico dei processi non lineari del secondo e del terzo ordine, il lavoro analizza i principali vincoli fisici che ne determinano l’efficienza nei dispositivi integrati, includendo phase matching, dispersione, confinamento e perdite. Sulla base di queste considerazioni, la tesi esplora s...

Toward telecom-compatible fiber-based quantum communication: frequency-bin quantum key distribution and a novel optical quantum memory

Characterization and analysis of quantum processes: Learning-based approaches to quantum channels, positive maps and optical neural networks

Renormalisation of Quantum Cellular Automata

Quantum Cellular Automata (QCA) provide a general framework for local, discrete-time dynamics: a locality-preserving update acts uniformly on a lattice, enforcing finite information speed and well-defined causal structure. This dual viewpoint—as dynamical systems with causal cones and as parallel algorithms on distributed registers—supports applications across information theory and computation, many-body physics, and quantum field theory. Yet connecting microscopic update rules to emergent l...

Radiomics-Driven Analysis and Phantom Design for Lung MRI and Diffusion Imaging

Magnetic Resonance Imaging (MRI) is a core biomedical imaging modality that provides high soft-tissue contrast and multiparametric information without the use of ionizing radiation. The increasing complexity and dimensionality of MRI data have progressively driven a shift from qualitative image interpretation toward quantitative and data-driven approaches, with radiomics emerging as a key methodology for imaging-based biomarker development. However, radiomic features are often sensitive to ac...

Design, Implementation and Commissioning of an Ultrafast XUV Ptychography Beamline

This thesis work focuses on the design, implementation and commissioning of a tabletop beamline for Ultrafast Ptychography experiments using eXtreme UltraViolet (XUV) coherent light. Through High-Harmonic Generation (HHG), femtosecond pulses from a titanium-sapphire regenerative amplifier are coherently upconverted to produce harmonic combs centered at 42.6eV and 96.5eV. The generated radiation retains high spatial and temporal coherence, enabling the implementation of Ptychography, a techniq...

Development of the HiDRa highly granular dual-readout calorimeter prototype and search for heavy neutral leptons with the ATLAS experiment

This thesis presents the work carried out during my Ph.D. at the University of Pavia and INFN, divided into two main lines of research. The first describes the development of a highly granular dual-readout calorimeter prototype, named HiDRa. The second outlines a search for beyond the Standard Model particles called Heavy Neutral Leptons (HNLs) with the ATLAS experiment at the LHC. The HiDRa project is part of the detector R&D programme for future lepton colliders such as FCC-ee (CERN) and C...