Dissecting the secretome of amniotic mesenchymal stromal cells to find new therapies for cardiac diseases

The high worldwide incidence of cardiovascular diseases has driven the development of novel therapeutic approaches. Mesenchymal stromal cells (MSCs) have been widely investigated in preclinical models of heart diseases, showing significant therapeutic benefits. It is well-established that MSCs primarily exert their therapeutic effects through paracrine mechanisms mediated by their secretome. However, MSCs derived from elderly donors or individuals with chronic conditions exhibit reduced regen...

Valorizzazione della biodiversità fungina per lo sviluppo di metodiche a basso impatto per il biorecupero di metalli di interesse industriale

Dallo studio tassonomico alla produzione vivaistica: approccio integrato alla conservazione di specie vegetali rare

Data la sua ricchezza di specie e l’alto tasso di endemismo, L’Italia rappresenta un’importante area per la conservazione della biodiversità in Europa. Tuttavia, le indagini più recenti hanno lasciato dubbi in merito al rischio di estinzione per molti taxa. Il presente progetto mira a contribuire alla conservazione delle specie italiane indagando tre principali punti riguardanti la conservazione delle piante: (a) la tassonomia; (b) la genetica di popolazione; e (c) la produzione vivaistica. ...

Development of a SiN photonic circuit for the stabilization of C-band semiconductor lasers

The future of high-bandwidth communications requires the on-chip generation of several lines with the aim of improving the spectral efficiency of optical channels and reduce the power consumption. With the recent technological advancements, semiconductor lasers could address this challenge. Unfortunately, these components are very sensitive to thermal fluctuations and their operational frequency could be severely affected by the action of closely spaced devices. A compact and dynamic method t...

Tuneable mid-infrared sources for spectroscopy through difference frequency generation in Lithium Niobate ridge waveguides

Over the past two decades, significant advancements have been made in the miniaturization of mid-infrared (MIR) spectroscopy sources. However, achieving a fully integrated solution presenting high optical power and wide tuneability within the so-called atmospheric window (2.5 – 5 μm) remains an open challenge. This thesis explores the development of a broadband, frequencytuneable MIR source exploiting the effect of difference frequency genera tion (DFG) in a Periodically Poled Lithium Niobate...

Biocatalytic green transition of industrial processes to produce cephalosporin and carbapenem antibiotics

Il lavoro di tesi si concentra sullo studio e ottimizzazione della sintesi enzimatica della cefazolina, un antibiotico cefalosporinico ampiamente utilizzato in ambito clinico. L’obiettivo è proporre un processo alternativo al metodo chimico tradizionale, caratterizzato dall’uso di solventi tossici e reagenti clorurati, sviluppando una sintesi sostenibile e scalabile a livello industriale. La reazione, sotto controllo cinetico, tra 7-ZACA e TZA-Me, catalizzata dall’enzima PGA, offre significat...

Origin of mafic-ultramafic rock sequences from the Ivrea Mafic Complex (Southern Alps): new insights into the process of magmatic underplating

A Versatile Workflow for Building 3D Hydrogeological Models Combining Subsurface and Groundwater Flow Modelling: A Case Study from Southern Sardinia (Italy)

This research project aims to develop a basin-scaled 3D hydrogeological model by using Petrel E&P (Petrel 2021© ) as the basis for a numerical groundwater flow model developed with “ModelMuse”. A relevant aspect of the project is the use of Petrel 2021© geologic modelling tools in the field of applied hydrogeology to improve the details of both hydrogeological and numerical groundwater flow models, and their predictive capabilities. The study area is located in South Sardinia (Campidano Plai...

Plio-Pleistocene Evolution of the Po Plain Subsurface: Insights from a 3D Geological Model and its Relationship with the Occurrence of Thermal Anomalies for Geothermal Energy Exploration