Characterization of BACE1/BACE1-AS/β-amyloid axis in cardiovascular risk conditions: exploring its pathophysiological miRNAs connection

Beta-Secretase 1 antisense (BACE1-AS) long non-coding RNA is an antisense transcript of BACE1, the key-rate limiting enzyme for the production of β-amyloid (Aβ), which is involved in the pathogenesis of Alzheimer's disease (AD). It is known that BACE1-AS stabilizes the BACE1 mRNA both directly and preventing its degradation through the sequestration of BACE1-targeting miRNAs, leading to increased levels of Aβ production [1]. Given the growing evidence of a correlation between cardiovascular a...

Discriminative ability and responsiveness to rehabilitation of a set of trunk acceleration-derived gait indexes in subjects with gait disorders due to central nervous system diseases

This dissertation investigates the discriminative ability and responsiveness to rehabilitation of trunk acceleration-derived gait instability indexes in individuals with neurological conditions, specifically Parkinson’s disease and primary hereditary cerebellar ataxia. Using a single magneto-inertial measurement unit placed at lumbar level during steady-state walking, this research aims to enhance the assessment of gait abnormalities, fall risk, and rehabilitation outcomes. The resulting seve...

Genotype-phenotype correlation and functional mechanisms of RFC1 repeat expansion causing CANVAS and sensory neuropathy

Materiali Innovativi per Scissione dell'Acqua

Questa tesi di dottorato esplora lo sviluppo di eterogiunzioni per la produzione fotocatalitica di H2 e NH3 verde, affrontando le sfide globali energetiche e ambientali. La ricerca dimostra che la progettazione delle interfacce dei materiali, dei meccanismi di trasferimento elettronico e della morfologia migliora le performance fotocatalitiche. Lo studio si concentra principalmente sul carbonitruro grafitico (g-C3N4) come fotocatalizzatore verde. I risultati principali includono l'ottimizzazi...

Beyond muscle: a multidisciplinary approach to the involvement of the Central Nervous System in neuromuscular diseases

This PhD project focused on the neuropsychological profile of pediatric patients with Duchenne Muscular Dystrophy and the implementation of technological devices in their rehabilitation. In this disease it is known the relationship between dystrophin deficiency and neurodevelopmental disorders and neuropsychological impairments, which are frequent but often overshadowed by the more apparent motor disabilities. With the advent of novel treatments there is an even more urgent need to address th...

Conformational antibodies to proteolipid protein-1 and its peripheral isoform DM20 define clinical subgroups within CNS autoimmune demyelinating diseases

In recent years, the identification of MOG and AQP4 conformational antibodies has completely revolutionized the diagnostic approach to autoimmune demyelinating diseases (ADD). These autoantibodies assist in recognizing patients with specific conditions, termed NMOSD for AQP4-IgG and MOGAD for MOG-IgG, which necessitate management distinct from that of multiple sclerosis (MS). In this context, several neuroglial targets have been investigated as potential biomarkers for ADD, with proteolipid p...

An 8-bit 800 MS/s Voltage and Time Domain Hybrid ADC Design

The main goal of this work is to have a suitable ADC design that is going to be used as the unit converter in a time interleaved ADC structure for higher conversion rates. To keep the input capacitance at minimum while preserving high conversion speed, a hybrid structure of time based ADC and a flash ADC conversion scheme is utilized. A new time to digital converter (TDC) with free running oscillator as time domain quantizer is introduced instead of using a conventional voltage controlled osc...

Assessing behavioural traits and ecological impacts of invasive crayfish species in freshwater ecosystems

Le invasioni biologiche comportano l'introduzione e la diffusione di specie in aree non autoctone, con conseguenti impatti ecologici, economici e sociali. Le specie invasive si trovano negli ecosistemi terrestri, d'acqua dolce e marini, con gli ecosistemi d'acqua dolce particolarmente minacciati dalle attività umane e dai cambiamenti ambientali. I gamberi di fiume, i più grandi invertebrati delle zone temperate, sono modelli di ricerca interessanti per le loro caratteristiche, come gli sposta...

Sistemi ibridi di nanoparticelle di metalli nobili e fluorofori e nanoparticelle di Blu di Prussia per inchiostri fototermici visibili

La tesi verte sulla realizzazione di inchiostri fototermici contenenti nanoparticelle (NP) in tre distinti progetti. 1) è stato ottenuto un inchiostro contenente NP sferiche d’oro funzionalizzate con un fluoroforo, di cui è stato ottenuto il quenching completo della fluorescenza, con rilassamento termico in seguito a irraggiamento, dunque con un'ulteriore banda di assorbimento fototermicamente attiva, oltre a quella della NP d'oro. 2) nello studio su inchiostri fototermici utilizzabili in con...