Monitoraggio concentrazione plasmatica nuovi anticoagulanti orali sulla popolazione afferente al Pronto Soccorso: confronto tra due metodiche e interpretazione clinica, studio prospettico osservazional e

Questo studio osservazionale prospettico ha esaminato la concordanza di due metodi—un saggio cromogenico anti-Xa e la LC-MS/MS—per la quantificazione delle concentrazioni plasmatiche di anticoagulanti orali nuovi (NOACs) in un contesto reale di pronto soccorso (PS). La popolazione dello studio comprendeva 80 pazienti (44 donne, 36 uomini; età mediana 85 anni) in terapia cronica con NOAC (apixaban, dabigatran, edoxaban o rivaroxaban) che si sono presentati al PS dell'IRCCS Policlinico San Matt...

Advancements in Biologic Therapies for Severe Chronic Rhinosinusitis with Nasal Polyps: A Phase IV Study

TEMPORARY MECHANICAL CIRCULATORY SUPPORT IN CARDIOGENIC SHOCK: ANALYSIS OF SURVIVAL RATES

Background and Aims: Cardiogenic shock (CS) mortality remains high, ranging from 30 to 60% in-hospital and from 40 to 60% at 1 year. The aim of the present study is to determine the survival (at 30 days and 1 year) and the predictors of 30-day mortality in a cohort of patients treated with temporary mechanical circulatory support (MCS) devices for CS. Methods: Retrospective observational study including adult patients treated with temporary MCS devices for CS in a tertiary level cardiothoraci...

Prediction of long-term drug-free outcomes in ACPA-positive and -negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year prospective study

Objective: To delineate, within the framework of current clinical practice and criteria, the sustainability of first-line immuno-suppressive treatment discontinuation in rheumatoid arthritis (RA) and the impact of residual disease in remission on long-term drug-free (DF) outcomes. Methods: RA patients, referring to the Pavia Early Arthritis Clinic (EAC) between 2009 and 2021 and achieving remission after DAS-driven methotrexate (MTX) monotherapy, were recruited. Eligible patients underwent D...

COMPLESSITA’ FISIOPATOLOGICHE, DIAGNOSTICHE E TERAPEUTICHE DELL’ARTRITE REUMATOIDE SIERONEGATIVA

L’artrite reumatoide sieronegativa (AR-SN) rappresenta una forma complessa e meno studiata di artrite reumatoide (AR), caratterizzata dall’assenza di biomarcatori sierologici specifici come il fattore reumatoide (FR) e gli anticorpi anti-peptide ciclico citrullinato (ACPA). Questa condizione pone significative sfide diagnostiche e terapeutiche, poiché i pazienti spesso ricevono una diagnosi tardiva, ritardando l’inizio delle terapie. La presente tesi si propone di esplorare diversi aspetti de...

Multidimensional management of severe pediatric asthma: from diagnosis to personalized therapy

L'asma grave pediatrico è una malattia cronica eterogenea caratterizzata da frequenti esacerbazioni e limitazioni significative della qualità di vita. Nonostante i progressi terapeutici, persistono ancora importanti unmet needs nella comprensione dei meccanismi patogenetici, nell’identificazione di possibili biomarcatori e nella gestione ottimale di questa condizione. Abbiamo riscontrato una prevalenza complessiva dell'asma grave nei bambini del 3% senza differenze significative tra maschi e ...

ALL Digital Clock Generator and PLL-Less Solution

This thesis presents an innovative design of a Fractional Output Divider (FoD) and its enhanced version, the All-Digital Fractional Output Divider (ADFOD). The FoD adopts an open-loop structure, eliminating the need for traditional Phase-Locked Loop (PLL) feedback control. Through digital techniques, it dynamically adjusts both integer and fractional division ratios, while precisely regulating phase interpolators to generate output clock frequencies ranging from 1 MHz to 300 MHz at a working ...

Placement Strategies in Cloud Continuum Environments

The increasing deployment of Internet of Things (IoT) applications across diverse domains, such as healthcare, manufacturing, and smart cities, introduces new challenges in the efficient utilization of computational resources. To ensure timely execution of applications and reduce response times, effective application placement within the cloud continuum, comprising cloud, fog, and edge infrastructures, plays a critical role. The inherent heterogeneity of these infrastructures, coupled with th...

An Optimization and Manufacturing Approach To Support the Design of Patient Specific Hip Prostheses