Study of the epigenetic regulation of HAX-1 in Friedreich's ataxia

F the deficiency of the mitochondrial protein Frataxin (FXN), as a result of a GAA triplet expansion mutation. Frataxin is required for cell survival and is involved in iron metabolism, with proposed function in iron-sulfur clusters biogenesis, heme biosynthesis and redox regulation. Its deficiency gives rise to a complex pathophysiology that affects not only the nervous system but also cardiac function. Two thirds of patients develop hypertrophic cardiomyopathy that often progresses to heart...

Three essays on the implementation of circular procurement management in italian electrical and electronic equipment (eee) supply chain

Circular procurement, recognized as a key aspect of achieving a sustainable circular economy, has gained prominence as a pivotal tool in recent years. Focused on transforming production and consumption patterns towards sustainability, it plays a crucial role in the circular supply chain. While various studies have explored circularity in different contexts, there is a notable gap in understanding the procurement perspective within the circular economy. Acknowledging the significant ripple eff...

Towards a multi-ends leadership for the common good for business and society

The ex-situ machine perfusion experience in a midvolume liver transplant centre: are we pushing the limits?

Liver transplantation (LT) is the accepted curative treatment for end-stage liver disease, with one and five-year survival of 90% and 70%, respectively1 . With increasing rates of liver disease2 , the supply of transplantable organs is no longer able to meet demand. In UK, despite substantial waiting list mortality (namely 21%), only 63% of deceased donor livers are transplanted. Between January 2018 and December 2019 in Italy, out of 2750 effective donors (i.e. donors from which at least one...

Routine and molecular diagnostic tools for mutations raising concerns monitoring in plasmodium falciparum endemic disease proteome: multiclonal infection multiplicity, allelic marker msp genetic polymorphism, pf-haplotypes circulating recombinant form, HRP-2/3 gene deletions and anti-malarial drug resistance mutations

Background: Malaria is one of the top three major diseases, caused most importantly P. falciparum (Pf). The fight against malaria continues to have obstacles in the Malaria elimination as difficulties to identify Plasmodium with gene deletion or drug resistance mutation. Here, we used different diagnostic tools. Information on circulating Malaria genotypes and mutations can help to take the appropriate decisions. Methods: Febrile children aged 10 days to 15 years suspected of malaria were rec...

Fabrication & characterization of perovskite solar cells and modules via manufacturing techniques

Organic-inorganic halide perovskite solar cells (PSCs) have recently sparked a lot of interest in academia and industry, as seen by the rising number of articles in the field. Despite the booming power conversion efficiencies, the commercialization of PSCs is impending. The primary bottlenecks are the relatively lower stabilities when compared to their silicon counterparts and lack of knowledge to transfer skills from lab-scale techniques to industrially manufacturable techniques. This doctor...

Actin cytoskeletal defects in Primary Immunodeficiencies: characterization of radiation-induced DNA-damage repair and actin cytoskeleton dynamics in patients affected by ARPC1B deficiency

The increasing identification of Primary Immunodeficiencies (PIDs) caused by new inborn errors of immunity in genes encoding for actin regulatory proteins highlights the essential role of actin dynamics in immune function. Indeed alterations of filamentous (F)-actin assembly and disassembly affects the cytoskeleton remodelling impairing numerous cell functions including mitosis and cytokinesis, mobility, phagocytosis, intracellular signalling and intercellular interactions as well as particul...

Le trasformazioni di Roma attraverso i Piani Regolatori dal 1962 al 2021: marketing elettorale, partecipazione civile e confronto politico

Perovskite on flexible foil: from lab to real-world application

Perovskite solar cells (PSCs) have attracted substantial interest in the photovoltaic community, owning to a very fast achievement in its efficiencies greater than 25%. However, for any solar cell to enter the market and maintain its share, two main additional milestones need to be achieved: long-term operational stability and industrial production capability. This was the focus of my research, where I investigated novel device architectures that are stable over the state-of-the-art and optim...