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Università degli Studi di Salerno: [596] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 596
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Salerno 2014 Knowledge management and Discovery for advanced Enterprise Knowledge Engineering -
Università degli Studi di Salerno 2017 Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases) -
Università degli Studi di Salerno 2016 La filosofia pratica e l’ascesi nelle Quaestiones ad Thalassium di Massimo il Confessore -
Università degli Studi di Salerno 2012 Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response -
Università degli Studi di Salerno 2017 Design and synthesis of peptides involved in the inhibition of influenza virus infection -
Università degli Studi di Salerno 2016 Umanesimo e post-umanesimo: lo sguardo della pedagogia generale -
Università degli Studi di Salerno 2014 p53 regulates Mevalonate Metabolic pathway -
Università degli Studi di Salerno 2016 Models and Algorithms for Some Covering Problems on Graphs -
Università degli Studi di Salerno 2015 Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents. -
Università degli Studi di Salerno 2011 Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products -
Università degli Studi di Salerno 2012 Biophysical investigation of biomolecules in bio-membrane models -
Università degli Studi di Salerno 2016 New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing -
Università degli Studi di Salerno 2008 Studio teorico-sperimentale sulla statica delle volte in muratura. -
Università degli Studi di Salerno 2008 Sul legame costitutivo viscoso di laminati di FRP per rinforzo strutturale. -
Università degli Studi di Salerno 2008 I grandi spazi della città: la piazza e... -
Università degli Studi di Salerno 2008 Modelli di misurazione e diffusione della democrazia : l'Unione europea nel contesto internazionale. -
Università degli Studi di Salerno 2008 Modelli di vita familiare. Rappresentazioni sociali e informazione statistica : un’indagine nella provincia di Salerno. -
Università degli Studi di Salerno 2008 Fare l’Europa sociale : dimensione sociale europea e welfare nazionali in relazione. -
Università degli Studi di Salerno 2008 Autonomia contrattuale e trasmissione della ricchezza familiare. -
Università degli Studi di Salerno 2008 Analisi comparatistica del diritto d'autore in internet : tendenze attuali e prospettive future. -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 596
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Prodotti recenti

Knowledge management and Discovery for advanced Enterprise Knowledge Engineering

The research work addresses mainly issues related to the adoption of models, methodologies and knowledge management tools that implement a pervasive use of the latest technologies in the area of Semantic Web for the improvement of business processes and Enterprise 2.0 applications. The first phase of the research has focused on the study and analysis of the state of the art and the problems of Knowledge Discovery database, paying more attention to the data mining systems. The most innovative ...

Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)

JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires Fe(II) ion and α-ketoglutarate (2OG) as cofactors. The misregulation of these enzymes, in particular JMJD2 subfamily, has being significantly implicated in cancer initiation and progression. Potent and specific inhibitors of these enzymes have not been identified yet, most o...

La filosofia pratica e l’ascesi nelle Quaestiones ad Thalassium di Massimo il Confessore

The purpose of this study is to demonstrate how within the Quaestiones ad Thalassium the monk Massimo the Confessor’s reasoning is structured in two different perspectives: practical philosophy and mystical ascension. The idea behind this type of research is determined by two needs: the first one, obvious and tangible, is based on the scarceness of thorough studies on this worthy philosopher and theologian, whom for a long time was only considered for his suggestive critical interpretation of...

Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response

Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and protein conformational changes induced by ligand binding. The methodology utilizes a combination of multiple technical approaches: limited proteolysis, MALDI TOF MS, circular dichroism and Surface Plasmon Resonance (SPR) to determine the binding sites in signal transducer and a...

Design and synthesis of peptides involved in the inhibition of influenza virus infection

The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Previously, by protein-protein docking calculations, it was demonstrated that different loops of bLf C-lobe, corresponding to the sequences 418-429 (SKHSSLDCVLRP, 1), 506-522 (AGDDQGLDK...

Umanesimo e post-umanesimo: lo sguardo della pedagogia generale

The purpose of this PhD thesis is to examine in a pedagogical vision the transition period of the crisis of classical and philological humanism through the arrival and obsolescence of human sciences, up to the current current system which is called by many a kind of post humanism. This transition brings a new kind of pedagogical theorizing, from the context and frame in the sense of humanism to the context and frame of the sense of post humanism. This thesis signals the passage from a support...

p53 regulates Mevalonate Metabolic pathway

The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced expression of mevalonate pathway enzymes, including 3’-Hydroxy-3’-Methylglutaryl - CoenzymeA Reductase, Mevalonate Kinase, Farnesyl Diphosphate Synthase, Farnesyl Diphosphate Farnesyl Transferase 1. Three different cell lines have been considered, U343 MG (U343) and U251 MG (...

Models and Algorithms for Some Covering Problems on Graphs

Several real-life problems as well as problems of theoretical importance within the field of Operations Research are combinatorial in nature. Combinatorial Optimization deals with decision-making problems defined on a discrete space. Out of a finite or countably infinite set of feasible solutions, one has to choose the best one according to an objective function. Many of these problems can be modeled on undirected or directed graphs. Some of the most important problems studied in this area in...

Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents.

L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione di questi processi rappresenta uno dei principali obiettivi della moderna chimica farmaceutica. L’identificazione di nuove entità molecolari capaci di interferire con target biologici coinvolti in questi due meccanismi è altamente auspicabile per lo sviluppo sia di nuovi po...

Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; in fact it is over-expressed in several inflammatory disorders[1] as well as in some human tumours.[2;3] Hence, the inhibition of mPGES-1 has been proposed as a promising approach for the development of safer drugs in inflammatory disorders, devoid of classical NSAID side effe...

Scopri
Istituto
  • Università degli Studi di Salerno596
Data di pubblicazione
  • 20178
  • 201615
  • 201512
  • 20149
  • 20133
  • 20129
  • 2011134
  • 2010134
  • 2009127
  • 2008134
Settore disciplinare
  • Settore FIS/02 - Fisica Teorica, ...29
  • Settore SECS-P/08 - Economia e Ge...27
  • Settore M-FIL/08 - Storia della F...24
  • Settore BIO/15 - Biologia Farmace...22
  • Settore INF/01 - Informatica22
  • Settore ING-INF/03 - Telecomunica...19
  • Settore ICAR/08 - Scienza delle C...18
  • Settore L-LIN/10 - Letteratura In...16
  • Settore ICAR/09 - Tecnica delle C...15
  • Settore ING-IND/16 - Tecnologie e...15
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