Audiological characterization of X-linked mouse model

Alport Syndrome (AS) is a group of hereditary diseases caused by mutations in COL4A3, COL4A4, COL4A5 genes, these codify for polypeptidic chains of collagen type IV (respectively alpha3. alpha 4. alpha 5- a345), this network results the major collagenous constituent of the mature mammalian basement membrane (BM) of kidney (renal glomerulus), inner ear and eye. The molecular defect includes the synthesis, assembly, deposition, or function of the alpha3. alpha 4. alpha 5. The diagnosis of AS ...

impact of digital dentistry in daily prosthodontics

The goal of this Ph D thesis was to evaluate the impact of new digital technologies in the field of prosthodontics and to assess the advantages and disadvantages of them through in vivo and in vitro studies to implement their use in everyday practice. Firstly, in vitro studies for fixed and removable prosthodontics were conducted to test the devices and materials in laboratory without variables and potential confounding factors present in whole organisms and to evaluate parameters before tes...

Drought and the olive tree in a changing climate: a multi-level response characterisation to explore and valorise Italian cultivars

The Mediterranean climate faces significant warming and reduced rainfall due to climate change. This will make droughts more frequent and severe, affecting agriculture. Higher temperatures can damage crops while lower rainfall increases the need for irrigation. Despite that irrigation has sustained agriculture in arid regions, competition for water is increasing. To adapt to current challenges, improvements in irrigation practices, adoption of agro-ecological techniques and use of drought-tol...

MAGIC Observations of the Blazar TON 116 in a Multi-wavelength Context

This thesis focuses on the long-standing discussion on the blazar sequence intriguing the astrophysical community since the end of the '90s. Blazars constitute a subclass of Active Galactic Nuclei (AGNs) with a powerful radio jet pointing towards the Earth. They are characterized by a double-peaked Spectral Energy Distribution (SED), whose low-energy bump is thought to be due to synchrotron emission of electrons streaming in the jet, while the high-energy hump is likely due to inverse-Compto...

Sensori distribuiti in fibra ottica e tecnologie geomatiche per il monitoraggio della stabilità dei fronti di cava

La presente Tesi di Dottorato è incentrata sull’applicazione integrata di tecnologie geomatiche e Sensori Distribuiti in Fibra Ottica (Distributed Optical Fiber Sensors DOFS) per lo sviluppo di un sistema innovativo di monitoraggio finalizzato alla verifica della stabilità dei fronti di estrazione di tre cave di marmo delle Alpi Apuane: la “Cava Lorano I n° 22” (Carrara, Massa‑Carrara), la “Cava Piastra Bagnata” (Vagli di Sotto, Lucca) e la “Cava del Piastraio di Sotto” (Levigliani di Stazzem...

Global phosphoproteomic screening reveals a new function of CDK9 in DNA damage response.

Development of Advanced Tests for Bio-inspired Hybrid Organic Inorganic Electronic Devices

This thesis describes the management and development of an advanced testing platform for bio inspired hybrid organic-inorganic devices. with the help of external collaborators, perovskite (psc) and dye-sensitized solar cells (DSSC), luminescent solar concentrators (LSC) and neuromorphic organic devices (NOD) working as artificial synapses have been characterized in steady state and transient conditions on the system. The goal of the thesis is to correlate different advances optoelectronic cha...

Violence against Women in Anglophone and Hispanic Contemporary Literature

This doctoral thesis arises from the need to address the issue of women's invisibility as part of a broader movement encompassing violence against women and girls, which oppresses and affects them in the current heteropatriarchal society. This topic falls within the humanities with a feminist perspective, also covering aspects related to gender studies and sociology. The overarching objective is to investigate and analyze identity intersections concerning violence against women and the voices...

CRISPR-Cas9 gene editing: a new promising treatment for Rett syndrome

Rett syndrome (RTT) is a neurodevelopmental disorder affecting the central nervous system and is one of the most common causes of intellectual disability in girls, resulting in severe cognitive and physical disabilities. Mutations in MECP2 and FOXG1 genes cause the classic form and the congenital variant of Rett syndrome, respectively. Both genes are transcriptional regulators and both under- and over-expression of these gene cause disease in humans. To characterize the biological mechanisms ...