The present research project focused on two aims. The first concerned the definition and empirical validation of a scale for measuring restorative attitudes, which led to the identification of five fundamental dimensions of the construct. The second aim concerned the assessment of the impact of a restorative justice programme in a secondary school in northern Sardinia. The results of the study ...

Le relazioni tra la Sardegna e la Penisola Iberica tra il Bronzo Finale e la prima età del Ferro attraverso le testimonianze archeologiche (secoli XII - VII a. C.)

The thesis titled “Le relazioni tra la Sardegna e la Penisola Iberica tra il Bronzo Finale e la prima età del Ferro attraverso le testimonianze archeologiche (secoli XII–VII a.C.)” fits within the broader framework of Protohistoric Mediterranean navigation and contacts, with particular reference to the island of Sardinia and the Iberian Peninsula. It seeks to reconstruct the relationships that developed between these two areas during the Late Bronze Age and the Early Iron Age, based on materi...

Teriparatide nel trattamento dell'osteoporosi primaria e indotta da glucocorticoidi (GIO) in pazienti con Lupus Eritematoso Sistemico(LES): effetti sui marcatori del turnover osseo, e sui livelli sierici di osteoprotegerina(OPG), sRANKL, Interleuchina 6(IL -6) e Fattore di Necrosi Tumorale ? (TNF-? )

We studied the effect of treatment with teriparatide,a bone forming agent,on a group of 30 patients with postmenopausal osteoporosis and 20 patients with Systemic Lupus Erythematosus and GIO.Twenty postmenopausal women with osteopososis served as a control group and ere treated with oral alendronate.Markers of bone turnover(BAP,ICTP and Ost),serum levels of osteoprotegerin and sRANKL,IL-6 and TNF ? were measured under control conditions and after 12 and 18 months of therapy. Teriparatide ad...

Analisi dei trend epidemiologici di incidenza e prevalenza della Miastenia gravis nella popolazione sarda

Aim: Myasthenia gravis (MG) is a relatively rare autoimmune neuromuscular disorder. Over the last fifty years there has been a trend towards an increase of its prevalence. Last Sardinian report indicated a prevalence rate of 11.1 per 100,000 (1994) and an incidence rate of 0.8 per 100,000/year (1982-1994). We aimed to update MG incidence and prevalence in the Sardinian.
Methods: Patients with diagnosis of MG according to clinical, electrophysiologic and laboratory cr...

Effetti indotti dalla stimolazione elettrica trigeminale transcutanea sull'attività  EEG di soggetti sani e di pazienti con epilessia farmacoresistente

Aim: trigeminal nerve stimulation (TNS) induces an antiepileptic effect in experimentally induced epileptic animals, and a significant reduction seizures frequency in refractory partial epilepsy (RPE) patients. As far as we know, no information is yet available on the influence exerted by acute TNS on EEG activity of humans. We investigated the TNS effects on EEG activity of healthy subjects and RPE patients. Methods: ten patients and five healthy subjects were enrolled. Digital...

Istituzioni, società  , economia in una comunità  valdorciana: Montalcino (1361-1462)

The research has as object the analysis of social, political and economic dynamics of Montalcino between 1361 and 1462. The survey takes as its base a large part documentary of the rich documentation (now entirely novel) kept at the Archivio Comunale of Montalcino and at the Archivio di Stato of Siena. In the first part it explains the documentary material. It follows a description of geographical, orografic and hydrografic features. The second part has dedicated to the reconstruction of...

Ruolo della valutazione elettrofisiologica nella guida all'ablazione intraoperatoria in soggetti con cardiopatia congenita ed indicazione ad intervento di rimodellamento ventricolare destro

Aim: arrhythmias are common in grown up congenital heart disease (CHD) patients (pts).Pts with post surgical pulmonary regurgitation (PR) and right ventricular dilatation,may experience sudden death due to ventricular arrhythmias (VT).
Methods: adult pts with PR and RV dilatation requiring cardiac surgery were studied.Baseline EPS was performed. When VT was induced electroanatomical map (EM) of the RV was acquired and, during surgery, RF ablation was performed at sites ident...

La Stimolazione magnetica extracorporea del pavimento pelvico nel trattamento dell'incontinenza fecale

Aim: the objective of our study was to assess the clinical effects and anal pressures variations after extracorporeal magnetic stimulation in patients with fecal incontinence.
Methods: 26 patients affected by fecal incontinence (18 female and 8 male) were enrolled. The patients underwent a five-week corse of twice weekly, 20-minutes sessions. At the beginning and at the end of the treatment, Wexnerࢠs test for incontinence and anorectal manometry were performed. Al...

Studio dell'aggregazione cellulare in ceppi vinari di Saccharomyces cerevisiae

Among the different genes that regulate biofilm formation in strains of Saccharomyces cerevisiae, FLO11 plays a fundamental role. In a previous work we showed that FLO11 is required for air-liquid interfacial biofilm and we proposed a model for biofilm formation based on the ability of cells to entrap carbon dioxide, providing buoyancy. FLO11 belongs to the adhesin gene family, including FLO1, FLO5, FLO9 and FLO10 and the protein encoded by each gene has considerable sequence identity with ot...