Predatori. Rappresentazioni scientifico-letterarie dei rapporti tra essere umano e grandi carnivori in Italia tra Otto e Novecento

Nel corso dell’Ottocento naturalisti, editori e intellettuali italiani contribuiscono alla creazione di un fitto circuito di pubblicazioni zoologiciche e alla formazione di precise rappresentazioni scientifico-culturali dei grandi mammiferi carnivori (soprattutto lupo, orso e lince). L’arco cronologico in cui ciò avviene va dalla fine del Settecento, con le prime traduzioni buffoniane italiane, al primo decennio del Novecento, con il successo delle vite degli animali di Alfred Edmund Brehm, L...

Detection of prion-like proteins in human olfactory samples collected by nasal swabs

Le proteine simili ai prioni (prion-like) sono proteine con la capacità di autopropagarsi e diffondere intercellularmente trasmettendo la propria forma mal ripiegata a varianti normali della stessa proteina, come fanno i prioni. Sono coinvolte in numerose malattie neurodegenerative, causando morte neuronale. Ad oggi, rilevare queste proteine nei pazienti affetti è ancora una sfida. L’epitelio olfattivo mostra l’espressione di queste proteine nei pazienti affetti da diverse malattie neurodege...

Value of clinical neurophysiology in early management of neonatal hypoxic-ischaemic encephalopathy

Neonatal HIE is a complex neurological condition caused by an intrapartum or perinatal event leading to reduced cerebral perfusion. Therapeutic hypothermia (TH), the cornerstone treatment in HIE, should be instigated within six hours of birth and at present remains only indicated for term or near-term neonates with moderate or severe encephalopathy. TH use in mild encephalopathy is increasing internationally driven by concern that these infants are at risk of injury. The balance of risk again...

In silico analysis of pathogen-host interactions at molecular level

This study explores critical aspects of SARS-CoV-2 and Strongyloides stercoralis, focusing on structural variations, drug discovery, diagnostic challenges, and therapeutic strategies. Initially, it examines the emergence of a recurrent insertion in the N-terminal domain of the SARS-CoV-2 spike glycoprotein, highlighting its implications for viral evolution and vaccine design. An interaction-based drug discovery screen elucidates the mechanisms of known SARS-CoV-2 inhibitors and identifies pot...

ENZYMATIC AND MODERN MECHANICAL APPROACHES TO ISOLATE, AND CHARACTERIZE STROMAL VASCULAR FRACTION TO STUDY ADIPOGENESIS IN VITRO AND IN VIVO FOR ITS POSSIBLE APPLICATION IN RECONSTRUCTIVE AND REGENERATIVE MEDICINE

Element-based graph pangenome

Exploring promising biomarkers in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), affecting 2.3 million people worldwide, of which approximately 122,000 are in Italy. MS represents a multifactorial disease, typical of in young adulthood, whose cause is still unknown. An important role in the MS pathogenesis, seems to be played by inflammatory processes affecting the CNS associated with neurodegenerative phenomena with consequent alteration or loss of sensory, motor and cognitive ...

Competence-based VET curriculum enactment and its implications for vocational teachers and trainers’ practices and competence in Italy and Lithuania

Basandosi su casi di implementazione del curricolo di Istruzione e Formazione Professionale (IeFP) in Lituania e in Italia, la tesi offre una nuova prospettiva sulla contemporaneità e sulla rilevanza del curricolo basato sulle competenze (competence-based curriculum) per la pratica della IeFP e per gli studenti, sui suoi elementi definitori e sulle possibili variazioni a livello teorico-concettuale e normativo-governativo. Il modello di curricolo basato sulle competenze è applicato nei sistem...

Principio pattizio e rigidità costituzionale: dalle Chartes francesi alla realtà sovranazionale.

This PhD dissertation attempts to approach the concept of constitutional rigidity from the specific point of view of conventional sources: particular attention is devoted to the constitutionalism of the 19th Century, mainly to Statuto albertino and French Chartes of 1814 and 1830: thereafter, the analysis concerned the current international scenario. The purpose is to separate the theoretical concept of constitutional rigidity from the ways in which it is concretely guaranteed.