Intesa anticoncorrenziale e "contratti a valle": rimedi civilistici e regolazione del mercato

La presente ricerca ha per oggetto l’analisi, che prende le mosse dalla nota vicenda delle fideiussioni omnibus conformi al modello ABI del 2002, della complessa e stratificata tematica dei contratti “a valle” di un’intesa anticoncorrenziale e dei rimedi assicurati al terzo contraente estraneo a essa, con la cardinale pronuncia n. 41994/2021 delle Sezioni Unite a fare da ineludibile cornice. In particolare, dopo aver ricostruito gli orientamenti della giurisprudenza nazionale e le princi...

Integrative neuropathological and imaging study of multiple sclerosis: mechanisms of inflammation in intrathecal niches

Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system characterized by persistent neuroinflammation, demyelination, and neurodegeneration. In MS, inflammation becomes compartmentalized within intrathecal niches, including the meninges, choroid plexus (CP), and perivascular spaces, sustaining chronic immune activation. Histopathological analysis of 40 MS cases identified subgroups defined by the presence or absence of tertiary lymphoid-like structures (TLS...

Gait training with intelligent treadmill for Parkinson’s disease (GaIT-PD)

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by degeneration of dopaminergic neurons in the substantia nigra, resulting in bradykinesia, rigidity, tremor, and marked gait disturbances. (Bloem et al., 2021; Tolosa et al., 2006). Spatiotemporal gait alterations, including reduced step length, increased cadence, decreased gait speed, and prolonged double support time, represent key factors contributing to impaired mobility and reduced functional independence...

Competenze interculturali nei luoghi di lavoro. Ricerca sulla gestione delle diversità in azienda per la promozione di buone pratiche

In contemporary contexts, professional environments are increasingly described as sites of innovation challenges. At the same time, workplaces must address the increasing diversity shaping Italian society, particularly since the early 21st century. This period has been marked by radical changes (Bauman, 2007; Beck, 2010; Portera, 2020), including a global pandemic that has questioned traditional work modalities. Working systems in organizations have become increasingly complex and dynamic, ev...

“Study on Blood Ethanol Stability in the Context of Driving under influence of Alcohol Investigations”

Driving under the influence of alcohol is a major public health and legal issue, as a substantial proportion of traffic accidents are associated with alcohol consumption. In Italy, Articles 186 and 186-bis of the Highway Code establish legal thresholds for blood alcohol concentration (BAC) and impose sanctions according to specific limits (0 g/L, 0.5 g/L, 0.8 g/L, and 1.5 g/L) based on driver categories. Following ethanol determination in such cases, blood samples are typically stored at −20 ...

A multidimensional approach to eating disorders: exploring the psychological mechanisms associated with symptom severity

I disturbi alimentari sono disturbi mentali severi, associati ad una scarsa qualità di vita, ad un elevato rischio di mortalità e ad un significativo carico economico. Nonostante ciò, la ricerca scientifica in questo ambito rimane ad oggi limitata rispetto a quella condotta in altri settori della salute mentale. Un’area di ricerca che sta emergendo sempre più è quella dell’identificazione dei meccanismi transdiagnostici che sottendono lo sviluppo e il mantenimento dei sintomi alimentari. Tali...

c-FLIP mRNA-based engineering of Dendritic Cells: a new strategy for inducing long-term immune tolerance

Cellular FLICE-inhibitory protein (c-FLIP) è una proteina nota per il suo ruolo nella regolazione della morte cellulare programmata. Il nostro gruppo di ricerca ha dimostrato che l’overespressione di c-FLIP nei monociti induce un marcato riarrangiamento trascrizionale e funzionale che si traduce nell’acquisizione di proprietà immunosoppressive in vitro e in vivo. Considerati i limiti delle terapie cellulari basate sui monociti, le cellule dendritiche tollerogeniche (tolDCs) rappresentano un’a...

Natural History and Evolution of Conotruncal Anomalies Diagnosed Before 16 Weeks' Gestation: A Multicenter Retrospective Cohort Study

Ubiquitination of tau: challenges, methods and its role in neurodegeneration

Tauopathies, among which Alzheimer’s Disease is one of the best-known representatives, are a group of neurodegenerative diseases characterised by the accumulation of intracellular protein aggregates, known as Neurofibrillary Tangles (NFTs). NFTs are primarily composed of the Microtubule-associated protein tau. The function of tau and its conversion into pathological species are critically influenced by Post-Translational Modifications (PTMs), among which the role of ubiquitination remains poo...