Identification and characterization of anti-caries natural compounds and their use in experimental slow release tablets as advancement of oral health strategies.

The intent of this research program was to determine a new way in caries prevention. The score was the development of new formulation for topical administration of natural anti-caries active compounds in the oral cavity. Mucoadhesive tablets containing CPP-ACP, Stevia rebaudiana Bertoni and pomegranate peel extract, after excluding any citotossic activity, were performed .The tablets have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. On the basis of the results obtained from this research, the usage of mucoadhesive buccal drug delivery system could be a novel route of anticaries bio-active molecules administration by offering prolonged contact at the site of administration and satisfying the compliance of the patients.