BIOLOGICAL CHARACTERIZATION OF NEW POLYMERIC AND COMPOSITE BIOMATERIALS IN THE ORTHOPAEDIC AND ODONTOIATRIC RESEARCH

In the present study, the biocompatibility and efficacy of polylactide/polyglycolide copolymers (PLA-PGA) 50/50 dispersed in different porous matrices were evaluated. Moreover, a polycaprolactone based material was also tested as porous bone space maintainer or as a scaffolding material. The aim of the present thesis was to comparatively investigate the in vitro and in vivo behaviour of these materials for the treatment of bone loss pathologies. Their biological characterization was studied by means of both in vitro and in vivo tests: the in vitro part had the purpose to assess the cellular biocompatibility and the in vivo steps to evaluate the tissue compatibility and functionality of the materials, as stated by the ISO (International Organization for Standardization) guides and, finally the preclinical efficacy to treat bone losses secondary to teeth extractions.