The transplant of the uterus

Objective: to estimate the number of potential donors and potential recipients per year for uterus transplantation in the Italian setting. Setting: referral center for transplant and reproductive medicine. Design: survey, retrospective analysis. Patient(s): Patients affected by Mayer-Rokitansky-Küster-Hauser syndrome and deceased donors from 2001 to 2018. Intervention(s): analysis in detail of the deceased donors used in Tuscany from 2001 to 2018 accordingly with a uterus transplant protocol elaborated in our hospital, survey among patients affected by Mayer-Rokitansky-Küster-Hauser syndrome Main Outcome measure(s): estimated number of donors and recipients for uterus transplant per year. Result(s): the number of potential usable donors is estimated in 97 per year in Italy and the number of potential candidates to uterus transplant resulted at least 1,400.We report a pilot survey between women affected by Mayer-Rokitansky-Küster-Hauser syndrome. Thirteen out of 54 (24%) patients responded to a specific questionnaire, 92% have a strong will of motherhood and think UTx an effective solution; 70% are interested in UTx but do not fully understand if the benefits exceed the risks. Conclusion(s): in Italy the need of Utx is real and the number of donors is reasonable to start a pilot clinical trial. Information is mandatory, as it is necessary to create a dedicated multispeciality team to follow candidates before, during and after the path to transplantation