Organocatalytic Desymmetrization Reactions: Catalyst-Controlled Enantio-, Atropo- and Diastereotopic Group Selection for the Synthesis of Central and Axial Stereogenic Elements

Desymmetrization reactions has emerged as a cutting-edge approach in recent years for the synthesis of enantioenriched compounds. The demand of enantiopure organic compounds in the pharmaceutical and fine chemical industry increased in the recent years giving the impetus to the development of new chiral technologies. Among them, the catalytic asymmetric synthesis represents the economically-optimal route to obtain chiral building blocks. During the course of my PhD we investigated the use of organic catalysts to promote the formation of enantioenriched products from achiral or meso- starting materials.