Binding sites on G-protein Coupled Receptors. Implications in Design of Bivalent Ligands and Allosteric modulation

This thesis is aimed at providing an overview about the relevant role played in drug design by the knowledge, at a molecular level, of ligand (drug)-receptor (biological terget) interactions as well as paths that ligands should follow to reach their binding site(s) within the receptor. This research led at developing a basic approach for rational design of ligands, which are endowed of particular mechanisms, that is bivalent ligands and allosteric modulators, of interaction with the receptor of interest.