From the genesis to the application: design of cocrystals based on natural ingredients and monitoring of their synthesis and activation

The aim of this thesis is the stabilization of natural EOs through cocrystallization with designed coformers. The coformers were synthesized in order to show photo-responsive properties and well interact with the selected EOs. The release of the resulting cocrystals was evaluated upon UV radiation and dark conditions. As a second purpose, the mechanism of two mechanochemical cocrystallizations was investigated with different techniques. Both the reactions involved thymol (EO) as coformer and showed the presence of low melting eutectic compositions that act as liquid intermediates. The nature of low eutectic composition was further explored using the Pair Distribution Function (PDF ) analysis. Finally, a systematic study on binary mixture systems was proposed in order to estimate ab initio the thermodynamical requirements to obtain low melting eutectic systems.