CLINICAL AND CLINICOPATHOLOGICAL MARKERS IN THE MANAGEMENT OF CANINE CHRONIC LIVER DISEASES

The thesis explores clinical and clinicopathological markers in the management of canine chronic liver diseases (CLD), drawing parallels with human liver disorders. Key topics include metabolic disturbances, the role of the gut-liver axis, and extrahepatic manifestations. The research presents findings on serum amino acid and vitaminic imbalances, lipid metabolism, in affected dogs. Studies on the gut microbiome suggest a potential gut-liver axis in dogs, with the use of synbiotics improving gut health. Other investigations cover kidney injuries, pancreatic-biliary associations, and the impact of hyperlipidemia on liver health. The thesis emphasizes a multidisciplinary approach to CLD management, integrating nutritional strategies, anti-inflammatory treatments, and emerging diagnostic tools like elastography and immunohistochemical markers. As human CLDs, canine CLDs represent complex pathologies with potential multi-organ and metabolic involvement and therefore require a multimodal therapeutic management. The study underscores the need for further research to develop comprehensive therapeutic strategies tailored to dogs, similar to advances in human medicine.