Bacillus subtilis as Mucosal Adjuvant

Recently, researches attention has been focused on the development of mucosal immunity strategies based on the use of probiotic spores as mucosal adjuvant. Therefore, they represent a good adjuvant to deliver antigens into the gastrointestinal tract and they could be used to mucosal vaccine. The mucosal vaccinology was used also for down-regulating inflammatory conditions. Among these conditions, celiac disease (CD) represents a very interesting model to test possible immunomodulatory strategies. So the aim of my research has been the use of Bacillus subtilis spores as a display system to development an immunomodulatory strategies for celiac disease.