The Bacillus subtilis spore: assembly of surface proteins and biotechnological applications

In my phD project I studied well-known model organism Bacillus subtilis. Bacillus subtilis is a model organism to study a variety of biological phenomena, ranging from gene expression to microbial differentiation, protein-protein interactions and formation of subcellular structures. In addition, this organism is also widely studied for biotechnological reasons, from enzyme and antibiotic production to surface display and vaccine delivery. I am particularly interested in both aspects and, therefore, I decided to focus my attention firstly, on the post-translational regulation of two crucial morphogenetic proteins, CotE and CotH, and secondly, on gaining a better understanding of the non-recombinant approach for surface display on bacterial spores.