microRNAs (miRNAs) are key regulators of different basic cellular processes. A number of miRNAs have been found to be dysregulated in many disease settings, most notably cancers. The role of miRNAs in systemic sclerosis (SSc), as well as in other fibrotic disorders has been scarcely investigated. Here we analyzed miRNA expression profile in SSc and identified miR-145 as a deeply down-regulated miRNA in SSc dermal fibroblasts and skin, which plays a crucial role in the regulation of the TGF-beta pathway in vitro and in vivo.
miR-145 is a key regulator of the TGF-? signaling pathway in systemic sclerosis and counteracts experimental fibrosis
2013
Abstract
microRNAs (miRNAs) are key regulators of different basic cellular processes. A number of miRNAs have been found to be dysregulated in many disease settings, most notably cancers. The role of miRNAs in systemic sclerosis (SSc), as well as in other fibrotic disorders has been scarcely investigated. Here we analyzed miRNA expression profile in SSc and identified miR-145 as a deeply down-regulated miRNA in SSc dermal fibroblasts and skin, which plays a crucial role in the regulation of the TGF-beta pathway in vitro and in vivo.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
PhD_thesis_vettori.pdf
accesso solo da BNCF e BNCR
Tipologia:
Altro materiale allegato
Licenza:
Tutti i diritti riservati
Dimensione
2.68 MB
Formato
Adobe PDF
|
2.68 MB | Adobe PDF |
I documenti in UNITESI sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Utilizza questo identificativo per citare o creare un link a questo documento:
https://hdl.handle.net/20.500.14242/338322
Il codice NBN di questa tesi è
URN:NBN:IT:BNCF-338322