Studies on the role of cholesterol in the pathogenesis of prion diseases: I. Correlation between cell susceptibility to prion infection/replication and altered cellular cholesterol distribution

The aim of the research project was to investigate whether cell susceptibility to prion infection/replication was somehow related to alterations in the intracellular cholesterol homeostasis, and in particular whether unbalanced FC vs. CE pools could be found in prion infected/prion susceptible cells with respect to cell conditions of no infection or genetic resistance.