-Novel indole-1-carbinols and 1,3'- Diindolylalkanes: synthesis and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells: preparation of tris-oxazoles building blocks for the total synthesis of telomestatin

The first chapter of this thesis work describes an efficient and ecofriendly synthetic methodology of the known 1,3'-diindolylalkanes, which were recently brought to the forefront for their anti-carcinogenic properties. With a similar procedure, novel indole-1-carbinols and 1,3'-diindolylalkanes were synthesized and then subjected to preliminary cytotoxic evaluation on hepatocarcinoma cells, showing to be great potential anticancer drugs. The second chapter explores possible solutions to the unresolved issue presented by the oxidation of a dihydro precursor of the potent telomerase inhibitor, telomestatin. The assembly of key polyoxazole building blocks for that natural product is discussed.