Polymer Physics and structural organization of chromosomes in mammalian genomes

Chromosomes in mammalian cell nucleus have a very complex spatial organization, linked to important functional purposes. In this PhD thesis, we show that the organization is hierarchical from very low length scales up to entire chromosomes scale. Then, we use polymer physics to describe general aspects of chromosome architecture. Finally, we presents polymer physics based computational methods to accurately reconstruct the 3D structure of real loci of the genome.