Standard TRUS guided prostate biopsy Vs new multiparametric approach using transrectal SE and CEUS. A randomized controlled study.

In our study we demonstrated that adding the dimension of perfusion imaging using a combined approach of transrectal SE and CEUS resulted in a significant decrease in false-positive results and improved the positive predictive value of correctly identifying histopathological cancer, but, the cost of the imaging, the increase in the time and in the complexity of the diagnostic process, did not support the availment of this method, especially if compared with the our detection rate with standard TRUS guided biopsy.