Novel insights into gold(I) chemistry: from anticancer activity to new synthetic methodologies.

The work herein presented, embraces various aspects of gold chemistry: the documentation of novel [alkynyl(triphenylphosphine)gold(I)] complexes carrying differently substituted propargylic amines and their pharmacological investigation on a series of cancer cell lines and the investigation of the dearomative cycloaddition reaction of indoles with electron-rich allenes catalysed by commercially available gold(I) complexes that show competence in performing the chemo-, regio- and diastereoselective formal [2+2]-cycloaddition between a wide range of substrates under mild conditions. It has also been developed the combined efficiency of Bu4N+ and F? ions in performing a cascade sequence involving intramolecular hydroamination of the C†"C triple bond, cleavage of silyl-protecting groups and site-selective sigmatropic aza-Cope-type [3,3]-rearrangement.