Wolfram syndrome: investigating the visual phenotype of Wolfram mice models, the functionality of wolframin protein, and the role of astrocytes in the pathology; developing a AAV vector-based gene therapy to treat the optic atrophy in Wolfram mice models

Wolfram syndrome: investigating the visual phenotype of Wolfram mice models, the functionality of wolframin protein, and the role of astrocytes in the pathology; developing a AAV vector-based gene therapy to treat the optic atrophy in Wolfram mice models

Unveiling the pathophysiological basis and developing a gene therapy approach for Wolfram syndrome

VANNI, NICCOLÒ NATANAELE
2026

Abstract

Wolfram syndrome: investigating the visual phenotype of Wolfram mice models, the functionality of wolframin protein, and the role of astrocytes in the pathology; developing a AAV vector-based gene therapy to treat the optic atrophy in Wolfram mice models
13-mar-2026
Inglese
Wolfram syndrome: investigating the visual phenotype of Wolfram mice models, the functionality of wolframin protein, and the role of astrocytes in the pathology; developing a AAV vector-based gene therapy to treat the optic atrophy in Wolfram mice models
Wolfram syndrome; Neurodegeneration; Macroglia & neurons; Gene therapy; Mice models
BROCCOLI, VANIA
AURICCHIO, ALBERTO
Università Vita-Salute San Raffaele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14242/363652
Il codice NBN di questa tesi è URN:NBN:IT:UNISR-363652