Inflammation represents a key factor connecting aging, cardiovascular disease and gut health. Epigenetics regulation and mitochondrial homeostasis play a pivotal role in this interplay. A healthy, balanced diet has been hypothesized to counteract chronic inflammation supporting healthy aging. Thus, the aim of this doctoral thesis was to investigate the transcriptomic, epigenetic and mitochondrial mechanisms characterizing inflammation, focusing on the responses to nutritional bioactive molecu...
Mosquito-borne diseases represent a significant public health
concern worldwide, with pathogens such as arboviruses and
filarial parasites posing substantial risks to both humans and
animals. In Mediterranean regions, including Italy and Greece, the
distribution and population dynamics of mosquito species are
influenced by a range of ecological, environmental, and
anthropogenic factors. Among the most prominent vectors in these
areas are Culex pipiens and Aedes albopictus, two species ...
The thesis explores the legal dimension of sustainability in the energy sector, analysing
how it shapes the governance of renewable energy and local participation. It focuses on
Renewable Energy Communities (RECs) as innovative legal entities within the
European and Italian frameworks for the ecological transition. Through the lens of
sustainable development law, the research examines how the principles of
environmental protection, social inclusion and subsidiarity influence contractual
...
This research work is part of the framework of public policies oriented towards ecological
transition, decarbonization of the economy and strengthening territorial cohesion. The survey
focuses on the role of Energy Communities and Green Communities as legal, economic and
social instruments capable of promoting sustainable development and energy autonomy in the
Italian Internal Areas, territories often marked by depopulation, infrastructural marginalization
and energy poverty. The thesis ...
Opioid use disorder is a multifactorial neuropsychiatric condition characterised by compulsive
drug-seeking behaviour despite adverse consequences, and it remains a significant global
public health concern. The widespread prescription of opioids for chronic pain has
contributed to escalating rates of misuse, dependence, and overdose. This doctoral thesis
investigates the genetic, molecular, and environmental factors involved in opioid use
disorder, with the aim of elucidating mechanisms ...
Landfill leachate represents one of the most complex environmental challenges due to its highly pollutant impact. In fact, it is rich in ammonium nitrogen (NH4+-N), recalcitrant organic compounds and heavy metals. Traditional wastewater treatment plants (WWTPs) struggle to handle this pollutant, especially when leachate matures, standing for a long time in landfill, and becomes increasingly difficult to be biologically treated. This research aims to explore innovative solutions to this pressi...
Open data plays a crucial role in modern digital governance by enabling transparency, fostering
innovation, and supporting data-driven decision making. Despite the growing prevalence of open
data ecosystems, they still remain supplier-driven, exclusive, linear, and best-effort-based.
Contempo rary governance principles call for their evolution into a more user-driven, inclusive,
circular, and skills-based model. Beyond general principles of the ecosystem, their effectiveness is
also gaug...
Background: An altered functional innervation of the intestine by the enteric nervous system (ENS)
has been demonstrated in different pathologies. Pathological changes in histological features confirm
neuronal plasticity in metabolic syndrome and related obesity conditions, in gastrointestinal disorders
like Inflammatory bowel diseases, (IBD), and among other pathologies also in Alzheimer’s disease
(AD). Changes in functionality and composition of gut microbiota and intestinal dysbiosis s...
Efficient scheduling of production processes is a cornerstone of modern manufacturing, directly impacting operational performance and cost efficiency. In the realm of manufacturing and production, flowshop scheduling plays an essential role in optimizing production scheduling to improve efficiency and reduce idle times. In the traditional flowshop scheduling problem, each job can only proceed to the next machine after completing processing on the current one, potentially leading to idle times...
Digital interconnection of “smart” devices (IoT) and the rise of distributed-ledger technology (DLT) have enabled self-executing agreements, smart contracts, capable of acting without human oversight.
Celebrated for their potential to enhance efficiency, these technologies also press against foundational legal principles. This thesis investigates the tension between code-driven contracting and European constitutional guarantees, including legal certainty, individual autonomy, and effective j...