PROGETTAZIONE E VALIDAZIONE DI UN NUOVO SISTEMA DI NEBULIZZAZIONE DI TIPO PNEUMATICO PER IL TRATTAMENTO DELLE PATOLOGIE DELLE ALTE E BASSE VIE AEREE

DESIGN AND VALIDATION OF A NEW PNEUMATIC DEVICE FOR THE TREATMENT OF HIGH RESPIRATORY TRACT DISEASES The aim of this PhD project was to design and develop a new nebulization device for the treatment of upper and lowe airways with these features: penumatic type, withour electricity, with low cost and high compliance, which can allow large volume of solutions, not only irrigation but also nebulization, not only saline solution but also drugs. At the ending of our activities, we developed a n...

THE AGONIST-ANTAGONIST MYONEURAL INTERFACE (AMI) IN THE SURGICAL REVISION OF UPPER LIMB AMPUTATION FOR THE PROPRIOCEPTIVE FEEDBACK AND ADVANCED CONTROL OF BIONIC POLYARTICULATED PROSTHESIS

Currently, in Europe, at least 100,000 people suffer from major upper limb amputations, with an annual increase of 2%. Advanced poly-articulated prostheses, which interpret user intentions from electromyographic (EMG) signals recorded via surface electrodes on residual muscles, are commercially available. This non-invasive signal collection method can be affected by various factors such as temperature, sweat, electromagnetic fields, and movement artifacts. Additionally, these prostheses allow...

Acufene somato-sensoriale e disturbi dell’articolazione temporo-mandibolare: sviluppo di test diagnostici e di terapie riabilitative per la valutazione ed il trattamento neuromuscolare

Tinnitus is the perception of sound in absence of a corresponding external acoustic stimulus. Somatosensory Tinnitus”, differently, is a tinnitus evoked or modulated by inputs from somatosensory, somatomotor e visual motor systems in some individuals. Inputs from these system seems to activate auditory patterns, leading to a “modulation” of tinnitus. Modulation can occur after a forceful muscle contractions of the temporomandibular joint (TMJ), head and neck, and limbs, pressure application...

NEUROPHYSIOLOGICAL CORRELATES OF COGNITIVE DECLINE IN A COHORT OF ALZHEIMER’S DISEASE PATIENTS: A MULTIMODAL LONGITUDINAL STUDY

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, with a dramatic socio-economic impact. Despite advancements in the diagnostic process thanks to the introduction of in vivo biomarkers of amyloid and tau pathology, the need for robust predictors of disease progression remains critical. This study aims to identify neurophysiological markers that best predict disease progression in AD patients. Methods: This was an observat...

Autologous mesenchymal stem/stromal Cells for the Treatment of workers affected by chronic low back pain due to multilevel InterVErtebral disc degeneration: a phase IIB randomized clinical trial

Background: Low Back pain is a highly prevalent disabling condition in the general population. It is estimated that 50-80% of adults have experienced at least one painful episode in their lifetime. It can be associated with physically demanding jobs, as well as sedentary occupations, low levels of physical activity. The degeneration of the intervertebral disc is recognized as one of the most significant causes of low back pain. Degenerated discs thus have a lower water content than normal dis...

Incisional negative pressure wound therapy (INPWT) in the prevention and treatment of post-sternotomy mediastinitis

Deep sternal wound infection (DSWI) occurs in 1-5% of all patients undergoing median sternotomy, with an incidence of 30-40% in case of high risk patients. DSWI greatly increases both morbidity and mortality, with much pain and discomfort for the patient. Recently, many approaches have been reported to reduce the risk of DSWI. Negative Pressure Wound Therapy (NPWT) is classically applied after surgical debridement to improve the microcirculation conditions in the wounds. Incisional negative ...

Validation of a machine learning algorithm for the prediction of first anti-seizure medication response in focal epilepsy: a multicenter cross-sectional study

INTRODUCTION For people with epilepsy, the EEG is a pivotal neurophysiological technique for confirming the diagnosis and guiding clinical management. However, no definite EEG prognostic biomarkers for anti-seizure medications' (ASMs) efficacy have been defined. AIMS The purpose of this study is to use a machine-learning (ML) approach to determine the predictive power of conventional scalp EEG for seizure freedom in a population of newly diagnosed focal epilepsy patients after a first ASM ...

ADDIO-BTcP " Evaluation of an UCBM Algorithm-Driven calculator of initial rapid-onset opioids Dose in Italian Oncological patients suffering from breakthrough cancer pain (BTcP): a randomized, multicentric, prospective, phase II trial”

MINIMALLY INVASIVE COLECTOMY UNDER NEURAXIAL ANESTHESIA IN FRAIL PATIENTS. SPICO STUDY

Introduction. General anesthesia is the most widely used anesthesia technique for major abdominal surgery, but it may have longer recovery time, high cost and environmental impact. In addition, general anesthesia may be contraindicated in some frail patients. Our study aims to evaluate the feasibility and safety of performing colorectal surgery with minimally invasive technique, in frail patients, under spinal anesthesia. Then we compared this group of patients with a retrospective one, perfo...