Symbolic Computation Methods for the Numerical Solution of Dynamic Systems Described by Differential-Algebraic Equations

In modern engineering, the accurate and efficient numerical simulation of dynamic systems is crucial, providing valuable insights across various fields such as automotive, aerospace, robotics, and electrical engineering. These simulations help to understand system behaviors, to optimize performance, and to guide design decisions. Nonetheless, systems described by Ordinary Differential Equations (ODEs) and Differential-Algebraic Equations (DAEs) are central to such simulations. While ODEs can ...

Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.

Spinal muscular atrophy (SMA) is a devastating disorder caused by deletions and mutations in the survival of motor neuron (SMN1) gene and is marked by motor neuron loss and muscle weakness. While its genetic basis is clear, the underlying molecular mechanisms remain elusive. Decreased levels of the survival of motor neuron (SMN) protein, encoded by the SMN1 gene, are implicated in SMA pathology. Despite splicing has been under the spotlight as a major mechanism impaired in SMA, recent evidenc...

Mimics of Protocellular and Extant Life

Our current scientific abilities do not allow for the synthesis of life in the laboratory. In order to reach this demanding goal, scientists are using cellular mimics of life to gain insight into the origin-of-life and the chemical complexity of biology and bioinspired systems. In the first part of this thesis, I characterize the behavior of prebiotically plausible single-chain lipids that can survive the – presumably – hostile conditions of the prebiotic Earth. Eventually, I aim to provide s...

A Geometric Singular Perturbation approach to epidemic compartmental models

We study fast-slow versions of the SIR, SIRS and SIRWS epidemiological models, and of the SIRS epidemiological model on homogeneous graphs, obtained through the application of the moment closure method. The multiple time scale behavior is introduced to account for large differences between some of the rates of the epidemiological pathways. Our main purpose is to show that the fast-slow models, even though in nonstandard form, can be studied by means of Geometric Singular Perturbation Theory (...

Application of avalanche detectors in scientific and industrial measurement systems

Therapeutic silk fibroin-based systems for tissue engineering applications

Tissue engineering (TE) is an interdisciplinary field, in continuous evolution, that possesses as main goal the creation of efficient systems for tissues and organs healing and regeneration. For bone, TE strategies are typically based on the combined use of scaffolds, cells, and bioactive molecules. Different materials were successfully studied and proposed for the fabrication of scaffolds. Among them, silk fibroin (SF) was evaluated as particularly promising for different TE applications, e...

Landslide Monitoring Using Radar Interferometry in the Alps

Decision-making In Different Cultures: Essays In Experimental Economics

A Content-Based Recommendation System for Leisure Activities

People’s selection of leisure activities is a complex choice because of implicit human factors and explicit environmental factors. Satisfactory participation in leisure activities is an important task since keeping a regular active lifestyle can help to maintain and improve the wellbeing of people. Technology could help in selecting the most appropriate activities by designing and implementing activities, collecting people profiles and their preferences relations. In fact, recommendation syst...