Human iPSCs-based CNS systems to model Autosomal Dominant Leukodystrophy

Autosomal Dominant Leukodystrophy (ADLD) is a rare, progressive, and ultimately fatal neurological disorder caused by overexpression of the nuclear envelope protein Lamin B1 (LMNB1), typically resulting from duplications of the LMNB1 coding region or deletions in upstream noncoding regulatory elements. Although LMNB1 is ubiquitously expressed, neurons and glial cells are particularly sensitive to dosage imbalances, leading to widespread white matter abnormalities and progressive neurological ...

Scomposizione e destagionalizzazione delle serie storiche economiche dottorato di ricerca in statistica metodologica

Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations

Development of High Entropy Alloys for High Temperature Applications

High Entropy Alloys, Spark Plasma Sintering, Ball milling, AlCoCrFeNI HEA, CO- Free HEA, Oxidation, Corrosion

Development of novel catalysts coated non-fluorinated proton exchange membranes for water electrolysis

Hydrogen holds great potential as an energy carrier due to its high specific energy and environmen-tal benefits. However, its current production mainly relies on fossil fuel-based methods, such as methane steam reforming, which result in substantial pollution and greenhouse gas emissions. To tackle this challenge, there is an increasing shift towards sustainable conversion methods, such as water electrolysis, which can produce hydrogen using renewable energy sources. Among the various electro...

Seismic behaviour of single-storey steel buildings connected to hybrid firewalls with fusible links

The seismic damage of non-structural components can lead tosignificant disruption in the functionality of buildings affected by fire and seismic events and result in considerable economic losses. Among non-structural elements, partition walls for several years were treated as architectural features and were not included in the structural design, although they can significantly influence the overall response of the structure. In recent decades, numerous seismic events have revealed the weaknes...

Alternative Food Landscapes. Designing Food-Sensitive Landscapes beyond Urban-Rural Bonundaries

In an era of accelerating urbanisation and climate change, integrating sustainable food systems into urban-rural landscapes has become a crucial strategy for developing resilient environments and communities. Contemporary food systems' weaknesses have been exacerbated by global crises like COVID-19 and geopolitical tensions, revealing vulnerabilities in urban-centric planning approaches. European initiatives, including the Green Deal and Farm to Fork Strategy, attempt to address t...

Probabilistic Ecosystems Assessment with Reinforcement Learning.

The health of marine ecosystems is crucial for planetary well-being, yet monitoring these dynamic and often remote environments remains a pressing challenge, further exacerbated by the impacts of climate change. Rising ocean temperatures, acidification, and habitat degradation are altering biodiversity distributions, increasing the need for rapid advancements in monitoring techniques. While current data collection techniques yield valuable ecological insights, they are frequently hindered by ...

Sediment transport modelling at the catchment scale in Alpine streams

Sediment management in river networks is of crucial importance for both environmental, productive and safety reasons. For instance, lost of sediment connectivity along river networks is recognized as a major cause of habitat degradation and biodiversity loss worldwide, and erosion/deposition processes may severely contribute to flood hazards. Also, artificial reservoirs may reduce their capacity to provide water in the quantity and time needed for the productive uses they were built, like irr...