Gold Nanorods-Encapsulated Extracellular Vesicles: A Smart Approach to Cancer Therapy

The development of effective nanomedicine strategies for cancer therapy requires not only materials with suitable physicochemical and optical properties, but also a detailed understanding of their interactions with biological systems. This thesis investigates inorganic nanomaterials from two complementary perspectives: understanding nanoparticle–biomolecule interactions and developing a bioinspired platform for photothermal delivery. The first part of the work focuses on hydrothermal carbon n...

La decisione amministrativa algoritmica. Discrezionalità, legalità e garanzie nell’età dell'intelligenza artificiale

Quando un algoritmo concorre a decidere chi ottiene un trasferimento, un contributo o una posizione in graduatoria, dove si colloca il potere amministrativo, e chi ne risponde? La tesi muove dall'ipotesi che l'ingresso dell'intelligenza artificiale nel procedimento non sia un fatto meramente esecutivo, ma imponga una rilettura di discrezionalità, legalità e sindacato giurisdizionale. Il filo conduttore è il "cono d'ombra", lo spazio della decisione storicamente sottratto al controllo giuridic...

Shaping Interaction in Virtual Reality Experiences for Access, Agency and Effects

Virtual Reality (VR) is now widely used across domains including entertainment, training, education, and healthcare, although its underlying concepts have also been explored in fields such as art and literature. Its value lies in its ability to reproduce physical-world locations, create environments that cannot be directly experienced in the physical world, represent phenomena that are otherwise inaccessible, and enable users to act and behave in ways that may not be possible outside immersiv...

Targeting Citron Kinase catalytic activity for high grade brain tumors treatment

High-grade brain tumors (HGBTs) are among the most lethal human cancers, characterized by extensive heterogeneity and intrinsic resistance to conventional therapies. Current treatments remain largely insufficient, highlighting the need for new therapeutic approaches. HGBT cells share molecular and functional traits with cortical radial glia cells, which exhibit severe defects in proliferation and survival when genes associated with primary hereditary microcephaly (MCPH) are inactivated. MCPH ...

Prendere spazio, prendere voce. Il Service-Learning e la Student Voice come pratiche inclusive nella didattica universitaria

Population dynamics and interactions between true bugs and their egg parasitoids, both indigenous and exotic, in agroforestry systems

The increasing importance of invasive and native stink bugs (Hemiptera: Pentatomidae, Acanthosomatidae and Coreidae) in agricultural systems has highlighted the need for sustainable management strategies based on a deeper understanding of their ecology and interactions with natural enemies. This PhD thesis investigated the population dynamics of true bugs and their egg parasitoids in the Alpine agroforestry landscape of South Tyrol (Northern Italy), with particular emphasis on the invasive br...

TEMPO, REATO, PROCESSO INTERSEZIONI TRA DIRITTO PENALE SOSTANZIALE E PROCESSUALE

L’entrata in vigore della l. 27 settembre 2021 n. 134 ha segnato un momento di svolta per la giustizia penale italiana. Tra le molte novità, il legislatore ha infatti introdotto nel codice di procedura penale una nuova ipotesi di improcedibilità dell’azione penale per superamento dei termini di durata massima dei giudizi di impugnazione (art. 344-bis c.p.p.). Oggi, dunque, la prescrizione del reato cessa di correre con la pronuncia della sentenza di primo grado, sia essa di condanna o di pros...

Personalisation in Dialogue Systems: From Accessible Interaction to Pragmatic Awareness

The thesis focuses on the personalisation of natural language technologies, particularly in dialogue systems, with the goal of addressing user-specific needs. The work aims to explore how personalised systems can better serve individual users by improving both the clarity of communication and accessibility, with a specific emphasis on users with disabilities. This doctoral research investigates the gap between current state-of-the-art language technologies and the real-world needs of users, a...

Protezione dei dati personali e amministrazioni pubbliche: tra tutela e riuso