EXTENSION OF THE LOCAL VIBRATIONAL MODE THEORY TO PERIODIC SYSTEMS

Methods for the advanced analysis of bio-signals acquired in a non-hospital environment for the support of fragile subjects

This PhD dissertation focuses on the design and validation of advanced methods for analyzing cerebral hemodynamic biosignals acquired through functional transcranial Doppler (fTCD), with the aim of supporting the rehabilitation and care of vulnerable individuals. The goal is to provide objective, non-invasive and accessible tools for functional brain monitoring following properly designed stimuli, particularly in patients recovering from stroke or affected by progressive neurodegenerative dis...

ASSESSMENT OF TRABECULAR BONE SCORE AS AN INDEX OF SKELETAL FRAGILITY ACROSS DIFFERENT SETTINGS OF SECONDARY OSTEOPOROSIS

Background: Osteoporosis is a chronic skeletal disorder characterized by reduced bone strength and an increased susceptibility to fragility fractures. While bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA) is the standard diagnostic tool, its limitations are evident in secondary osteoporosis, where many fractures occur in individuals with normal or osteopenic BMD. In these settings, skeletal fragility often depends on bone quality and microarchitecture, which are ...

NURSE-LED, PERSON-CENTRED CARE IN CHRONIC DISEASE MANAGEMENT: EVIDENCE, IMPLEMENTATION, AND IMPACT IN MYELOPROLIFERATIVE NEOPLASMS

Chronic diseases are the leading global cause of morbidity and mortality and require long-term, complex, and multidimensional management. Chronic haematological malignancies, including Myeloproliferative Neoplasms (MPNs), follow prolonged disease trajectories and are characterised by a substantial symptom burden with significant impairment in quality of life (QoL). Despite therapeutic advances, patients with MPNs require support for symptom monitoring and disease self-management. Increasing e...

MULTI-STAKEHOLDER APPROACH: CONCEPTUALIZATION, EVOLUTION, STRATEGIC AND TACTICAL APPLICATIONS IN MARKETING

This dissertation investigates how a multi-stakeholder orientation can move from a broad relational principle to a concrete managerial logic, and ultimately reframe marketing as a function able to create economic and societal value in the long term. Grounded in stakeholder theory and in the debate on responsible marketing, the thesis starts from a persistent problem: marketing is still frequently perceived as manipulative, short-term oriented, and detached from societal expectations. To addre...

Molecular and immunophenotypic biomarkers in dermato-oncology: insights from cutaneous melanoma and Sézary syndrome

The identification of reliable biomarkers represents a cornerstone of modern oncology, supporting early diagnosis, risk stratification, and treatment monitoring. Skin cancers constitute a particularly relevant field for biomarker research, encompassing both common malignancies such as cutaneous melanoma and rare but aggressive diseases like Sézary syndrome. Despite important therapeutic advances, significant challenges remain in both settings, highlighting the need for robust biomarkers capab...

Measurement of triple self-coupling of the Higgs boson in the four lepton decay channel with the CMS experiment

This doctoral dissertation presents the research performed in the area of detector technology development and of the measurement of the Higgs boson self-coupling using data from the CERN Large Hadron Collider (LHC). A study on Ultra-Fast Silicon Detectors was carried out to in view of future LHC timing-detector upgrades. In particular, the inter-pad region was studied in order to optimize the design regarding inter-pad width and fill factor. It was found that an inter-pad width of ∼ 25 μm is ...

Essays in the Economics of Education: Returns to Ability Signals

This thesis investigates how ability signals shape the returns to higher education and influence educational and professional trajectories. While human capital theory attributes labor market returns to productivity-enhancing skills, signaling theory emphasizes education’s role in conveying information about underlying ability. Contributing new causal evidence to this debate, the thesis examines three distinct signals, institutional prestige, relative class rank, and academic distinctions, and...

Mental Flexibility and Affect Dynamics: Theoretical Integration, Stochastic Modeling, and Experimental Paradigms

This doctoral dissertation investigates the dynamic interplay between affect dynamics and Flexibility, advancing a unified theoretical and methodological framework grounded in stochastic modelling and experimental research. Moving beyond static conceptualizations of emotion and executive functioning, the work adopts a temporal perspective in which both affect and Flexibility are conceived as processes unfolding over time and reciprocally influencing one another. The dissertation is structured...