Dried Blood Spot analysis as a sustainable and innovative approach for the detection of psychoactive substances and markers of alcohol abuse

Signal Transducer and Activator of Transcription 3 (STAT3) plays a plethora of different roles during tumor transformation and progression via both canonical and non-canonical, non-transcriptional functions. Among these, we have recently described STAT3 ability to control Ca2+ release from the Endoplasmic Reticulum (ER) and Ca2+-mediated apoptosis in STAT3-dependent Triple Negative Breast Cancer (TNBC) cells. This function is exerted via STAT3 localization to the ER and Mitochondrial Associat...

Harnessing Synthetic Lethal Interactions in Hematological Malignancies: Novel Therapeutic Approaches to Overcome Drug Resistance

Proteasome inhibitors (PIs) are commonly used to treat multiple myeloma (MM) and mantle cell lymphoma. However, many patients either relapse or are intrinsically resistant to these drugs. To identify targets that enhance the efficacy of PIs, we conducted a functional drug screening in the presence of the proteasome inhibitor carfilzomib (CFZ). This screening revealed synergistic interactions, with the ATP5F1C inhibitor bedaquiline (BDQ) and FDAapproved drug, and its fumarate form (BDQ-F), sta...

Pathophysiological and diagnostic evaluation of andrological and endo-gynaecological conditions through innovative analytical methods investigating androgen milieu

Le ripetizioni contrattuali: sistematica e decisione patrimoniale

GPU Porting of the PLUTO Code for Computational Plasma Physics using OpenACC

The simulation of astrophysical plasmas presents significant computational challenges because of the complex and dynamic nature of these systems. The PLUTO code, widely used for such simulations, traditionally relies on CPUbased computations. This thesis explores the porting of the PLUTO code to Graphics Processing Units (GPUs) using OpenACC, a directive-based parallel programming model designed for high-performance computing. The primary objective of this work is to enhance the computational...

The Identification of Climate Change Derived Risks to the Terroir Driven Grape and Wine Production of Nebbiolo in Barolo DOCG with the Development of a Prevention and Mitigation Strategy

Characterization and Testing of SO2 Poisoning Effect on Cu-CHA Zeolites

Integrating next generation sequencing in measurable residual disease detection and prognostic stratification of acute myeloid leukemia and myelodysplastic neoplasm

Advancing Multilingual DRS-based Semantic Parsing and Generation: A Framework for Data Transformation, Robust Evaluation, and Task Reversibility

Recent advancements in semantic parsing and text generation through Discourse Representation Structures (DRS) underscore the critical need for innovative methodologies to enhance neural model performance, particularly in multilingual and resourceconstrained environments. This research presents a comprehensive framework addressing these challenges through multiple complementary approaches: data transformation techniques, alternative evaluation methodologies, and task reversibility analysis. Th...