LIPASE AS AN INNOVATIVE PREDICTIVE TOOL TO DIRECT DECISION-MAKING STRATEGIES FOR HAZELNUTS INDUSTRIAL STORAGE AND QUALITY ASSESSMENT

Hazelnuts are among the most important raw materials in the confectionery industry, but their quality and shelf life are strongly limited by lipid degradation processes that lead to rancidity. Both oxidative and enzymatic deterioration pathways originate from the hydrolysis of triacylglycerols, a reaction catalyzed by lipases. Recent research identified the hazelnut allergen Cor a 8, a non-specific lipid transfer protein (nsLTP), as a novel lipase responsible for initiating lipid hydrolysis. ...

Rethinking Radiance Field Representations: Efficiency, Scalability, and Appearance

Radiance fields have emerged as a powerful paradigm for novel view synthesis, enabling high-fidelity scene reconstruction and rendering directly from multi-view image collections. Despite significant progress, three challenges limit their practical applicability: the computational cost of improving reconstruction quality, the lack of scalability in explicit representations under varying memory and bandwidth constraints, and the limited expressive power of commonly adopted directional appearan...

TECHNIQUES FOR MALWARE DETECTION AND ANALYSIS: A MACHINE LEARNING APPROACH

The rapid evolution of malware variants and the manual bottlenecks in reverse engineering demand automated, scalable, and resilient detection mechanisms. This dissertation investigates the application of machine learning and semantic feature extraction to mitigate human-in-the-loop dependency and address the degradation of classification models due to concept drift. The research is structured around three core contributions. First, it introduces SAUCY SPICE and its scalable evolution, Saucy E...

OCCURRENCE OF TRACE AND RARE EARTH ELE-MENTS (REE) IN MARINE FAUNA

This doctoral thesis investigated the distribution, bioaccumulation, and ecological effects of trace elements and rare earth elements (REEs) in three Mediterranean ecosystems character-ized by different hydrodynamic conditions: the Tyrrhenian Sea (open environment), the Venice Lagoon (semi-enclosed environment), and the Estany dels Ponts lagoon in Mallorca (confined environment). Due to the pronounced ecological and hydrodynamic differences among these sys-tems, different biological indicator...

Biomarker and Companion Diagnostics in medicinal products registration process: a bridge between the pharmaceutical and device worlds. Defining the right quality strategy considering the different phases of drug development: from research to phase III clinical trials

In recent years, medical advances in therapeutics and diagnostics have shed light on new aspects of clinical practice, laying the foundations for the so-called “personalized medicine” which uses molecular profiling to identify the most appropriate treatment strategy for the right person at the right time or to identify a predisposition to certain diseases enabling targeted and timely prevention. In many cases, the resulting treatment is based on predictive biomarkers which are a fundamental p...

Insegnare a scrivere nella scuola secondaria di primo grado: uno studio empirico sulle ricadute educative di una formazione in servizio al Writing Workshop

La presente ricerca di dottorato valuta le ricadute educative di una formazione in servizio sul metodo del Writing Workshop in un istituto comprensivo della periferia metropolitana di Torino, adottando il modello di Kirkpatrick (1959, 2006) come quadro di riferimento. Per osservare le ricadute educative della formazione sia sugli insegnanti che sugli studenti, lo studio si avvale di un disegno valutativo multifase a metodi misti (Fetters, 2013), articolato in due filoni paralleli. Il primo fi...

INNOVATIVE STRATEGIES FOR THE ACRYLAMIDE MITIGATION IN THE CEREALS SUPPLY-CHAIN

The acrylamide (AA) is a food process-contaminant classified as probably carcinogenic to humans (Group 2A) by the International Agency for Research on Cancer and highly widespread in cereal-based food products. Mitigation strategies for reducing AA in cereal-based foods include practices applicable at the field and processing levels. The aim of this PhD project was to identify agronomic strategies capable of limiting the concentration of ASN in the cereal kernels, and to mitigate AA formation...

Alterations of GABAergic transmission in models of neurotoxicity and neurodevelopmental disorders: molecular, synaptic, and functional mechanisms

NEUROLIGINS 1 AND 2, NEURONAL PROTEINS WITH A DUAL ROLE AT SYNAPTIC LEVEL, MODULATE SEPARATE FUNCTIONS IN ANGIOGENESIS