COMPARISON AND VALUE: CONSIDERING THE MODEL RIGHT TO DATA ERASURE

A modern extension from the data protection right to privacy, the Right to Erasure makes a world of difference in the online environment through its function to delete. Promoting the essence for a curb to access information freely whilst emergent technologies thrive in environments yet to feel the necessity for legal regulation and thereby permitting frictionless data usurpation. Central assessment concerning the right to data erasure (happens) with a focus from the internet users perspective...

NEWBORN SCREENING OF RARE GENETIC DISEASES: VARIANT DISTRIBUTION IN CYSTIC FIBROSIS AND MEDIUM-CHAIN ACYL-CoA DEHYDROGENASE DECIFIENCY

Introduction: Newborn Screening (NBS) is one of the most advanced tools in precision medicine because it enables the early diagnosis of selected inherited disorders so that an effective treatment can be started before irreversible organ damage occurs. Italian legislation (Law 104/1992 and Law 167/2016) states that more than 40 diseases are mandatory on Italian newborns. Cystic Fibrosis (CF) is the most common autosomal recessive genetic disorder with a poor prognosis in populations of Europea...

Adaptive Compression: From Visual Data to Efficient and Transferable Models

The exponential growth of visual content has made compression a fundamental challenge in modern communication systems. While traditional codecs achieved remarkable success, their rigid design limits their performance. Le

Next Generation Sequencing for the Detection of Adventitious Contaminants in Biotechnological Products

Adventitious biological contaminants may be unintentionally introduced during biomanufacturing of pharmaceutical products via cell banks, raw materials, or the environment. To ensure the biotechnological product safety and preserve patients’ health, different tests must be performed, as required by health authorities. The aim of my PhD project was to develop methods to rapidly detect different types of biological contaminants, utilizing next-generation sequencing (NGS) technologies for broad-...

Polymeric conductive nanocomposite materials for integrated metal-free cabling and sensing

doctoral thesis examines polymeric conductive nanocomposites for metal-free electrical cabling and sensing. By adding carbon-based fillers like graphene nanoplatelets, graphene oxide, reduced graphene oxide, and carbon black to thermoplastic polymers, this research aims to create lightweight, sustainable, and multifunctional materials. Moreover, an intensive study concerning a bio-based filler, such as lignin, used as a graphene precursor and dispersed within a biodegradable matrix, such as p...

UNDERSTANDING CLINICAL HETEREOGENEITY IN ANOREXIA NERVOSA: SOCIOEMOTIONAL PROCESSES, MOTIVATION, TREATMENT TRAJECTORIES

State of the art and purpose: Anorexia Nervosa (AN) is a severe psychiatric disorder with often unsatisfactory treatment outcomes. Understanding the factors underlying heterogeneity in clinical presentation and treatment response is essential for improving personalized care. This thesis applied up-to-date statistical methods to areas identified as relevant in AN: socioemotional processes (study 1), motivation to change (study 2), and in-treatment symptoms trajectories (study 3). Methods: S...

Deep Learning for Spatio-Temporal Environmental Phenomena and Application to Underground Water Resources

MAPPING CANCER-ASSOCIATED CELLS IN CONTEXT: A COMPUTATIONAL APPROACH TO MYELOID AND FIBROBLAST DYNAMICS IN CANCER

Cancer is a multifaceted disease, rooted in developmental process and fuelled by inflammation as an evolutionary driver. Timing is critical: in rapidly progressing tumours such as pancreatic ductal adenocarcinoma (PDAC), inflammatory loops stem from immune dysregulation driven by IL-1β– producing tumour-associated macrophages (TAMs); conversely, in more indolent malignancies like colorectal cancer (CRC), inflammation remodels the stromal–tumour interface to favor the emerging tumour micro-env...

Linking metabolic reprogramming to chemo-immuno-resistance: identifying new predictive biomarkers and druggable targets moving from OMIC techniques to single cell analysis

Non-Small Cell Lung Cancer (NSCLC) patients develop resistance to platinum-based drugs. The transcription factor CCAAT/Enhancer Binding Protein-β (C/EBP-β) affects chemoresistance by increasing the ratio between its two splicing isoforms LAP and LIP. LAP/LIP splicing reprograms metabolism of murine embryonic fibroblasts via non-coding RNAs (ncRNAs). In this thesis, we ex-plored the involvement of C/EBP-β splicing in driving cisplatin (Pt) resistance in NSCLC by promot-ing metabolic rewiring, ...