Freshwaters in a changing climate: effects of water scarcity on the (photo)chemistry of Alpine streams

The term “alpine” has two quite different meanings. When the word is capitalized, Alpine streams refer to running waters of the Alps, at any elevation. When not capitalized, alpine streams refer to running waters of the alpine zone above the tree line, anywhere in the world. In this PhD thesis, the first context was adopted. The work described in the following sections sought to examine, at least in part, the effects of climate change-related drought conditions on the chemistry of streams bor...

NOVEL DISEASE GENES DISCOVERY AND INNOVATIVE APPROACHES FOR INVESTIGATING NEURODEVELOPMENTAL DISORDERS

Neurodevelopmental disorders (NDDs) encompass a wide range of conditions, including Autism Spectrum Disorders (ASD), intellectual disability (ID), language delays, and epilepsy. These disorders exhibit significant genetic heterogeneity, involving all modes of inheritance. In the last years, the development of high-throughput technologies, like next-generation sequencing, has given the possibility to unravel the genetic mechanisms behind NDDs, and helped patients and their families to shorten ...

Design of a diagnostic kit for plasma quantification of antibiotics: from development to technical and clinical validation following IVD regulation (IVDR)

Background: Therapeutic drug monitoring (TDM) for antibiotic drugs represents a consolidated practice to optimize the effectiveness and to limit the toxicity of specific drugs by guiding dosage adjustments. The comparison of TDM results with drug-specific pharmacokinetic/pharmacodynamic (PK/PD) parameters, based on killing dynamics and bacterial susceptibility, increases the probability of therapeutic success. Purpose: The aim of this study was the analytical validation of a new UHPLC-MS/MS a...

METABOLIC MECHANISMS OF LIVER FIBROSIS PROGRESSION AND NON-INVASIVE BIOMARKERS OF FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE

Development of an innovative and sustainable coating for the protection of outdoor bronze artworks

Every outdoor bronze artwork is a one-of-a-kind creation with a distinctive history in terms of composition, production process and external exposure to the environment. However, they face a common problem: corrosion phenomena occurring over the surface promoted by degradation agents in the atmosphere. So, there is the need to choose the proper conservation method not to alter the aesthetic and the stability of these precious objects. The most widely used practice for protecting metals is app...

Regeneration Harnessing Nanomedicine-Based Strategies from Heart to Blood: Advancing Cardiac Repair and Human Hematopoietic Stem Cells Expansion

Testi / Icone / Iconot L’immaginario intermediale della tarda modernità. 1870-1930

Questa tesi ha come oggetti di studio l’iconografia letteraria, la retorica del visuale, il motivo figurativo e la grammatica dell’immaginario, ovvero tutte quelle forme di interazione e di co-implicazione tra parola e immagine che, al tournant de siècle, si concentrano in diverse costellazioni transnazionali. L’indagine è limitata a quella che Patrick Geary ha individuato come la parabola dell’imperialismo europeo (1870-1930) perché si spera così di ottenere una prospettiva sui mezzi e i met...

The Role of Property Rights on Sustainable Forest and Agricultural Land Use in Ethiopia: Examining Historical, Contextual and Policy Perspective

Tumori della muscolatura liscia uterina di potenziale maligno incerto: analisi retrospettiva multicentrica degli esiti di sopravvivenza e caratterizzazione molecolare mediante piattaforma NanoString

Il tumore della muscolatura liscia uterina a potenziale maligno incerto (STUMP) rappresenta una rara entità intermedia tra i leiomiomi benigni e i leiomiosarcomi. Questo studio retrospettivo ha analizzato 87 casi diagnosticati tra il 2000 e il 2020 in cinque centri di riferimento, con l'obiettivo di individuare i fattori di rischio per la recidiva. Diciotto pazienti (20,7%) hanno mostrato recidive, di cui 11 come leiomiosarcoma e 7 ancora come nuovo STUMP, con un tempo medio alla recidiva di ...