L’ALIENAZIONE DI BENI DI PROVENIENZA DONATIVA: TRA TUTELA (REALE?) DEI LEGITTIMARI ED ESIGENZA DI PROTEZIONE DELL’ACQUIRENTE O PROMISSARIO ACQUIRENTE

The main objective of this doctoral thesis deals with the intricate problem of the alienation of donated goods generally regarded as unsafe, due to the risk of claims by the donor’s forced heir. The problematic issue arises from the current succession law rules: in Italy, indeed, the deceased person’s close relatives (the spouse, the children and, in their absence, the ascendants) have the right to receive a certain portion of his/her estate. In particular, the injured forced heir (of that...

Building the bean pan-genome: how to build it and exploit its potential

The study of pan-genomes has become of crucial interest in genetic analysis. The reference genomes currently available are, in fact, no longer sufficient to represent all the variability within a species since they should collect genetic information that varies from individual to individual of the same population. A pan-genome is, therefore, a catalogue of all the genetic variations found within a population, species, or clade. Over time, different types of pan-genomes have been developed and...

Industrial Scene Analysis from a Human-centered Perspective through Intelligent Systems

The transition from Industry 4.0 to Industry 5.0 emphasizes the critical role of human-technology synergy in industrial environments, where artificial intelligence and robotics increasingly share workspaces with human operators. This research examines the advancement of human-centered industrial analysis through computer vision, investigating Human-Robot Interaction (HRI) techniques and introducing the novel concept of Human-Ambient Interaction (HAI). While HRI focuses on direct human-machine...

Innovative therapeutic approaches for neurodegenerative disorders: drug repurposing and cell therapy

Neurodegenerative diseases (NDs) are a group of heterogeneous disorders characterized by progressive dysfunction and loss of neurons that encompass many different entities. Due to a neuron’s impossibility of renewing itself, this loss is irreversible and is usually followed by the collapse of the structure and function of neural networks, triggering the breakdown of the core communicative circuitry. Involvement of functional systems differs between disorders and is associated with a broad spe...

Development of molecular tools and cellular models for the characterization of regulatory mechanisms of Tau protein alternative splicing

The human MAPT gene encodes Tau, a microtubule-stabilizing protein essential for cytoskeletal organization. Of the 16 MAPT exons, six of them are subjected to alternative splicing, generating a plethora of different Tau protein isoforms. The alternative splicing of exon 10 has been extensively studied over the years and, in particular, the imbalance in the expression of exon 10 isoforms has been associated with the development of Alzheimer’s disease. Additionally, Tau isoforms containing exon...

Il possesso del chiamato e la cautela oggettiva dell'eredità giacente

Lo scritto esamina l’attuale assetto del diritto successorio italiano in relazione all’amministrazione interimistica dell’eredità, evidenziando le lacune di tutela degli interessi dei soggetti coinvolti nella vicenda successoria e proponendo una valorizzazione della curatela dell’eredità quale strumento sussidiario di salvaguardia dei patrimoni ereditari nella fase di pendenza ereditaria. Viene illustrata criticamente l’interpretazione oggi dominante delle regole in tema di amministrazion...

Circ_0001591 contributes to melanoma cell migration by the sponge of miR-20a-3p and miR-34a-5p, leading to the upregulation of Axl and Fral proteins

Sviluppo e validazione di modelli e algoritmi di machine learning per la diagnosi precoce di malattie rare tramite analisi retrospettiva di ampie banche dati amministrative: risultati del progetto INSPIRE

L’acromegalia è una patologia endocrina rara causata dall'aumentata secrezione di ormone della crescita (GH) e del fattore di crescita insulino-simile 1 (IGF1), indotta, nella maggior parte dei casi, da un tumore ipofisario secernente GH. Sebbene l'acromegalia sia caratterizzata da evidenti manifestazioni fisiche e cliniche, i segni e sintomi a essa associati sono molto comuni nella popolazione generale e pertanto viene spesso diagnosticata in ritardo, influenzando così la sua prognosi a lung...

The journey of human neutrophils: from immature CD34+ progenitors to mature cells

A precise immunophenotypic and molecular characterization of neutrophil differentiation from CD34+ cells has not yet been fully explored. Recently, however, novel progenitors such as proNeus and eNePs have been identified, but these cells express the lineage markers CD66b and CD15, thus resembling promyelocytes (PMs) or more advanced maturation stages. In this context, our group more recently has identified four neutrophil-committed progenitors (NCPs) within the SSCloLin−CD45dim flow cytometr...