Perioperative NALIRIFOX in Patients with Resectable Pancreatic Ductal Adenocarcinoma: An Updated Analysis of Survival and Response Biomarkers from the Phase II nITRO Trial.

Introduction. Less than half of pancreatic ductal adenocarcinoma (PDAC) patients are alive after 5 years, even when diagnosed at an early stage. NALIRIFOX is a three-drug combination that has recently been shown to improve overall survival (OS) in advanced PDAC. The phase II, single-arm nITRO trial evaluated the activity of NALIRIFOX as perioperative treatment in patients with resectable PDAC (<180° contact with the wall of major veins). The study met its primary endpoint, achieving an R0 ...

L'Imaginaire de la langue italienne en France à l'âge classique entre polémique et fascination (1578-1754)

Studio sulla nozione giuridica di rappresaglia a partire dall'edizione (e traduzione) del "Tractatus de repraesaliis" di Bartolo da Sassoferrato alla luce della tradizione manoscritta.

Questo lavoro analizza il Tractatus represaliarum di Bartolo da Sassoferrato, uno dei maggiori giuristi del XIV secolo, per ricostruire la sua teoria delle rappresaglie e, attraverso essa, alcuni nodi centrali del pensiero giuridico e politico trecentesco. Nella prima parte (due capitoli) il trattato viene inserito nel contesto storico-giuridico dell’Italia comunale, caratterizzata dalla frammentazione delle giurisdizioni, dall’autonomia delle civitates e dall’assenza di un potere sovraordin...

Utterance structure in the initial stages of Polish L2 acquisition: from semantics to case morphology

This thesis is devoted to the processing of morphosyntax in the earliest stages of the acquisition of Polish L2, with special attention to the role of input and to elicitation techniques. The target structure of our work is the morphosyntactic opposition between the nominative and accusative case, respectively corresponding to the subject and object function. Within the VILLA project (Dimroth et al. 2013), 90 adult learners evenly distributed among five L1 groups (Dutch, English, German, Fren...

I sistemi commerciali tra Tardoantico e Altomedioevo ad Aquileia e in area altoadriatica: i luoghi, le merci

Il presente progetto di ricerca si propone di analizzare modi e tempi in cui il sistema commerciale altoadriatico si è trasformato tra IV e VI sec. d.C. Esso muove i propri passi a partire da questa domanda storica: “Quale impatto ebbero gli eventi politici, militari e ambientali verificatisi tra Tardantichità e Altomedioevo sulla realtà del tempo?” Per farlo si è scelto di utilizzare come lente di osservazione un sistema commerciale inteso come insieme di elementi impegnati nel trasferi...

Mechanistic insights into how CFTR dysfunction affects the host response to SARS-CoV-2 in bronchial epithelial models

Cystic fibrosis (CF) is a severe, inherited autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride and bicarbonate channel critical for epithelial homeostasis. Defective CFTR function impairs ion transport, alters mucus properties, and promotes chronic airway inflammation. Respiratory viruses are clinically significant in CF because they exacerbate lung disease; however, epidemiological data from the ...

Day/night variations of microglial morphology in the mouse lateral hypothalamus

Microglia are glial cells derived from mesenchymal progenitors (i.e., of the myeloid lineage). They provide the first line of defense against immune challenges in the central nervous system (CNS) and can be regarded as resident brain macrophages. They represent 10-15% of brain cells and are distributed throughout the CNS. Although several different microglial phenotypes have been identified through the years, in this study, we take into consideration a more classical definition with two sig...

Interpretable AI methods for prompt classification of temporal data

Essays on the economics of migration and labour: empirical evidence from the uk