Isolation, structural elucidation and evaluation of bioactivity of secondary metabolites from aromatic plants

Salvia tingitana Etl. is an aromatic woody-based perennial shrub original from the Arabian region. The analysis of the surface extract of the aerial parts afforded one nor-sesterterpene, eight new sesterterpenes and five known sesterterpenes, together with other known compounds that include five labdane and one abietane diterpene, one sesquiterpene and four flavonoids. The methanolic extract of the roots of S. tingitana was also investigated. Salvia corrugata Vahl. is cultivated in the Mediterranean coastal area as an ornamental plant. The methanolic extract of the roots and the twelve semi-purified fractions obtained by its chromatographic separation were tested against several multidrug resistant clinical strains.