VALUTAZIONE D’ESPRESSIONE DI MICRO-RNA IN PAZIENTI AFFETTI DA MIELODISPLASIA. UN POSSIBILE STRUMENTO UTILE PER LA COMPRESIONE DELLA PATOGENESI E DEI MECCANISMI DI PROGRESSIONE DI MALATTIA

The myelodysplastic syndromes are a group of diseases characterized by impairment in hemopoiesis and variable tendency to progress to acute myeloid leukemia. Recent data regarding the MDS pathogenesis highlight the presence of alterations in several compartments of DNA replication, cell cycle control and genes expression machinery. As previously reported miRNA families are involved in MDS pathogenesis. Also, different miRNAs have been characterized in AML and MDS and allow the identification of prognostic risk categories that are independent from the revised international prognostic scoring system (R-IPSS). Herein we report the results and the possible scenarios regarding pathogenesis and disease progression secondary the evidence of large gene network derangement following miRNA evaluation in a cohort of patients.