Modulazione della fosforilazione di stat1 in tirosina da parte di alcuni flavonoidi naturali

Flavonoids exhibit a variety of beneficial effects used in the treatment of a lot of pathologies such as inflammatory disease, cancer and cardiovascular disease. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanism such as inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) activation. In this work I analysed the anti-STAT1 activity of 26 flavonoids with strong antioxidant capacity. Among the analysed compounds only myricetin, robinetin and delphinidin are able to downmodulate STAT1 activation. The study of the molecular mechanism with biochemical and computer modelling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.