Dermatite atopica in età pedaitrica: correlazione tra scorad. livelli sierici di vitamina d, parametri strumentali e sensibilizzazione ad enterotossine stafilococciche e a malassetia furfur.

Atopic dermatitis is a chronic relapsing inflammatory skin disease with multifactorial etiology with a structural damage to the barrier of the skin. Recent studies have revealed a possible role of vitamin D. Indeed, vitamin D reduced the expression of CLA on the T cells, regulating the recruitment skin, increased the e3xpression of keratinocyte catelicidina at enhancing the antimicrobial defenses of the skin. Serious atopic dermatitis are often associated with the presence of IgE anti-staphylococcal toxins . The aim of our study is therefore to assess whether the severity of the disease quantified with SCORAD scores correlated with serum levels of vitamin D and with the presence of IgE anti staphylococcal toxins and M. Furfur and if the damage to barriers and awareness staphylococcal eneterotoxins depend on vitamin D itself. Materials and method: the severity of dermatitis was quantified by the SCORAD score that classifies the dermatitis in mild, moderate, serious using objective parameters as extent and intensity and subjective parameters as itching and sleep loss. To measure the trans epidermal water loss (TEWLS) we used tewameter. The IgE to staphylococcal enterotoxins A,B,C and to Malassetia furfur occurred on peripheral blood. The dose of vitamin D was considered sufficient to level >30 ng/L, insufficient >30 ng/L, lacking <20 ng/L. Results: the significativity of the date and the comparisons between the various groups studied was made by the statistical method of linear regression analysis. The correlation between the dose of vitamin D and the SCORAD was significant (p=0.016, r=0.38). Between vitamin D and TEWL is not statistically significant as well as between the does of vitamin D and IgE to enterotoxins A,B, C and M. furfur. The correlation between the sensitization and the SCORAD was not statistically significant as well as between vitamin D and sensitization. Conclusions: children with low serum levels of vitamin D have a SCORAD more high and therefore greater severity of disease. The study provides a good basis for further studies on the treatment of atopic dermatitis with supplementation of vitamin D.