Tissue regeneration: investigating drug delivery systems and new scaffolds manufacturing technologies

PLA-PCL electrospun matrices were developed for esophageal tissue regeneration. project focus on optimization of electrospinning process and in vitro physico-chemical and biological characterization for preliminary in vivo evaluation. PLA-PCL electrospun matrices were developed for esophageal tissue regeneration. Project focus on optimization of electrospinning process and in vitro physico-chemical and biological characterization for further preliminary in vivo evaluation. Electrospun matrices were loaded with two model drugs (Dexamethasone and Gentamicin) in order to study kinetic release.

Sono state sviluppate matrici elettrofilate a base di PLA-PCL finalizzate ad impianto sostitutivo temporaneo esofageo. Il progetto ha previsto ottimizzazione del processo di elettrofilatura, caratterizzazione chimico-fisica-biologica in vitro delle matrici, ora in sperimentazione su maiale. Matrici elettrofilate sono state caricate con Desametasone e Gentamicina per studiarne le cinetiche di rilascio