EFFETTO DEL MODERATO ESERCIZIO FISICO SUL SISTEMA Nrf2-ARE IN PAZIENTI CON CLAUDICATIO INTERMITTENS

Recent evidence suggests that exercise training can improve oxidative stress in patients with (PAD) with peripheral arterial disease (PAD) and intermittent claudication (IC), reducing inflammation and increasing walking ability. Although evidences demonstrating that exercise training significantly improves calf pain in patients with CI, the mechanisms are complex and not yet clear. The reactive oxygen species (ROS) produced during repeated episodes of ischemia-reperfusion (I / R) in patients with PAD and IC who undergo maximal exercise are the main cause of the endothelial reticulum stress and activate the '' Unfolded protein response "(UPR). Nrf2 (Nuclear factor-erythroid 2-related factor 2) plays a key role in regulating the antioxidant responses. The aim of this study is to evaluate if a period of three weeks of controlled exercise training in 24 patients with PAD (Fontaine stage II) and IC can improve the pain free walking distance and the maximal walking distance evaluated with Treadmill Test; improve oxidative stress measured as plasma malondialdehyde (MDA) and affect the Nrf2 / ARE signaling pathway in circulating PBMC of these subjects.