SURFACTANT BASED ORGANIC CHEMISTRY

This thesis explores sustainable organic synthesis methodologies, focusing on replacing traditional organic solvents with micellar media for the synthesis of active pharmaceutical ingredients (APIs), specifically in the green production of Perampanel, an antiepileptic drug. Following principles of green chemistry, the research investigates the efficiency and viability of water and micellar media as solvents in key reactions, including the Miyaura Borylation and Suzuki-Miyaura C-C coupling reactions. Emphasis is placed on micellar catalysis in aqueous environments to achieve high yields and selectivity while reducing environmental impact. The study demonstrates the practicality of water-based solvents, aiming to advance eco-friendly practices in industrial chemistry through reduced reliance on hazardous substances and enhanced sustainability of pharmaceutical manufacturing.