Neuroprotective effects of exercise in a MS experimental model

Multiple Sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting more than 2 million people worldwide and it is currently incurable [3]. MS typically affects young adults, with an onset between 20 years and 40 years of age and has a higher prevalence in women. The disease is characterized by a wide variety of neurological symptoms including muscle weakness, sensory, visual and cerebellar deficits, cognitive impairments, and psychic symptoms such as fatigue and depression. MS is primarily considered to be an immune-mediated disease characterized by the infiltration of autoreactive lymphocytes into the CNS resulting in a diffuse demyelination, neuroinflammation, neuroaxonal loss and dysfunction[4].