Telemedicine and neurodegenerative diseases: application of quantitative measurement tools - Telemedicina e malattie neurodegenerative: Applicazione di strumenti di misurazione quantitativa

Neurodegenerative diseases represent a challenge for healthcare systems worldwide, particularly in aging populations. This doctoral thesis explores how advanced technologies can enhance traditional assessment methods in the context of these conditions. Through a multidisciplinary and translational approach, the work investigates both cognitive and motor impairments in conditions such as Alzheimer’s disease and normal pressure hydrocephalus (NPH), integrating neuropsychological testing, neuroimaging, and wearable technologies. Chapters include original studies and reviews: from increased intrinsic functional connectivity in cognitively unimpaired older adults to the longitudinal evaluation of cognitive and motor outcomes following lumbar drainage in NPH. Furthermore, the role of technological tools and wearable sensors in the quantitative assessment of motor deficits is examined, along with their potential to overcome routinary traditional evaluations and allow a remote at-home monitoring. A novel experimental device is introduced as a wearable prototype designed to detect neurological symptoms, highlighting the possibility to shift toward a sustainable and data-driven healthcare. Ultimately, this thesis underscores the relevance of integrating emerging technologies with conventional practices, paving the way for more accessible, accurate, and environmentally conscious neurological care.