Within the range of the Virtual Biophysics Lab tumour growth numerical simulator, this work aims to develop a mathematical model able to describe the cell cycle desynchronization observed in the cell populations and the effects of DNA damage and repair due to ionizing radiation. Following a review of the already available models, some other original ones are proposed; one of these has been also tested on tumour cells by means of cytometry: the results of the related data analysis are not yet conclusive.
MODELS OF DNA DAMAGE, REPAIR, AND MISREPAIR
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2015
Abstract
Within the range of the Virtual Biophysics Lab tumour growth numerical simulator, this work aims to develop a mathematical model able to describe the cell cycle desynchronization observed in the cell populations and the effects of DNA damage and repair due to ionizing radiation. Following a review of the already available models, some other original ones are proposed; one of these has been also tested on tumour cells by means of cytometry: the results of the related data analysis are not yet conclusive.File in questo prodotto:
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Utilizza questo identificativo per citare o creare un link a questo documento:
https://hdl.handle.net/20.500.14242/266776
Il codice NBN di questa tesi è
URN:NBN:IT:UNITS-266776