ORGANOCATALYSTS BASED ON CONFORMATIONALLY BIASED CYCLIC PEPTOIDS

SINCE THE EARLY 2000S, ORGANOCATALYSIS HAS SEEN HUGE DEVELOPMENT THANKS TO ITS VARIOUS ADVANTAGES OVER METAL CATALYSIS, BUT ESPECIALLY DUE TO THE POSSIBILITY OF EASILY OBTAINING ENANTIOMERICALLY ENRICHED MOLECULES, WHICH IS PARTICULARLY INTERESTING FROM THE PERSPECTIVE OF SYNTHESIZING MOLECULES OF PHARMACEUTICAL INTEREST. AMONG THE NUMEROUS CLASSES OF COMPOUNDS INTRODUCED IN THE LITERATURE OVER THE YEARS, TWO ARE CERTAINLY OF PARTICULAR INTEREST: ORGANOBASES AND CHIRAL AMINES. VARIOUS COMPOUNDS ALREADY KNOWN IN THE LITERATURE ARE CURRENTLY USED; HOWEVER, RESEARCH IS STILL OPEN TOWARD THE SYNTHESIS OF NEW COMPOUNDS THAT ARE MORE PERFORMANT AND UNIVERSAL. FOR THIS REASON, THE AIM OF THIS PROJECT INCLUDES THE SYNTHESIS OF A NEW DABCO-BASED ORGANOBASE THAT IS C2-SYMMETRIC, CHIRAL, AND BIFUNCTIONAL. MOREOVER, ANOTHER AIM IS THE SYNTHESIS OF NEW CYCLOTRIPEPTOIDS THAT SHOW CONFORMATIONAL CHIRALITY, DECORATED WITH A PRIMARY AND TERTIARY AMINE IN THE SIDE CHAINS, WHICH TURN OUT TO BE VALID CANDIDATES AS ASYMMETRIC ORGANOCATALYSTS.