TRATTAMENTO ABLATIVO CON MICROONDE DI METASTASI EPATICHE DA TUMORE DELLA MAMMELLA: STUDIO DI FATTIBILITÀ ED EFFICACIA

INTRODUCTION Prognosis of patients with breast cancer liver metastases is still dismal. Some retrospective data support adjuvant surgery in selected patients. Ablative treatment in the management of breast cancer liver metastases remains controversial. MATERIAL AND METHODS We evaluated the efficacy (complete ablation and recurrence rate) and the safety (morbidity and mortality) of the microwave ablation treatment (MWA) of breast cancer liver metastases, performed in our Center from 2009 to 2016. Analysis was performed on a nodule-oriented and patient-oriented base. RESULTS Median time to liver metastases development was 52.13 months (IQR 25.5- 81.72), 92.5% of which were metachronous. Forty patients underwent 51 MWA sessions, percutaneously (27 sessions, 33 nodules) and laparoscopically (24 sessions, 67 nodules). Complete ablation rate for nodules =2 cm was 95.56% whereas the 3- and 6-months recurrence rate, irrespectively of the nodule dimension, was 12.73% and 26.19%, respectively. MWA was associated with no 90-day mortality. Morbidity rate was 20%. Two patients are alive and free of disease at 49 and 86 months, respectively.