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Università degli Studi di Padova: [7910] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 7.910
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Padova 2025 A HIGH-CONTENT IN VITRO SCREENING IDENTIFIES NEW MITOPHAGY-ACTIVATING COMPOUNDS -
Università degli Studi di Padova 2025 EXPLORING TRAP1 AS A NOVEL REGULATOR OF MACROPHAGES ASSOCIATED TO MALIGNANT PERIPHERAL NERVE SHEATH TUMORS -
Università degli Studi di Padova 2025 Assessing the relative role of adenine nucleotide translocator and ATP synthase in the permeability transition -
Università degli Studi di Padova 2025 Investigating the roles of F-ATP synthase subunits e and g in Drosophila melanogaster -
Università degli Studi di Padova 2025 Avalanches and oscillations in the brain -
Università degli Studi di Padova 2024 CARATTERIZZAZIONE DEGLI ASPETTI FUNZIONALI DEI DOMINI NON GLOBULARI -
Università degli Studi di Padova 2024 NUOVE PROSPETTIVE NELL'ERA DEI MODULATORI DEL CFTR: APPROCCI EMERGENTI PER IL MONITORAGGIO PRECOCE DELLA MALATTIA POLMONARE IN FIBROSI CISTICA -
Università degli Studi di Padova 2024 Next Generation Multiple Access Techniques for Wireless Communications -
Università degli Studi di Padova 2024 Deep Learning approaches for the functional inference of unknown proteins: Argot 3.0 -
Università degli Studi di Padova 2024 Control and Trajectory Generation Algorithms for high dynamics CNC machines -
Università degli Studi di Padova 2024 Intrasparenze. Conoscenza e razionalità nella teoria generale dei sistemi di Niklas Luhmann -
Università degli Studi di Padova 2024 Il paralogismo in Aristotele -
Università degli Studi di Padova 2024 Topological entanglement in proteins -
Università degli Studi di Padova 2022 Modulazione del microbiota intestinale aumenta l'effetto antitumorale di Radioterapia e terapia con cellule CAR T -
Università degli Studi di Padova 2024 Developing Scientific Practices in Secondary School: a Proposal for a New Curriculum -
Università degli Studi di Padova 2022 Metodi Parametrici e Nonparametrici per l'Analisi di Big Data nell'Innovazione di Prodotto -
Università degli Studi di Padova 2022 Profilo dell'interatoma di due canali ionici patologicamente rilevanti -
Università degli Studi di Padova 2025 Bayesian methods for borrowing historical information -
Università degli Studi di Padova 2025 Saggi di economia applicata -
Università degli Studi di Padova 2022 Identificazione e classificazione delle specie chimiche e dello sporco in bagni di lavaggio domestici -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 7.910
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Prodotti recenti

A HIGH-CONTENT IN VITRO SCREENING IDENTIFIES NEW MITOPHAGY-ACTIVATING COMPOUNDS

Mitochondrial diseases are a group of genetically determined and clinically heterogeneous hereditary disorders due to faulty oxidative phosphorylation (OXPHOS), a process mediated by five enzymatic complexes (cI-V) within the inner mitochondrial membrane. The aim of this thesis is to investigate the therapeutic potential of increasing mitophagy, a quality control pathway which selectively degrades dysfunctional mitochondria, for mitochondrial diseases. My goal was to identify new mitophagy-in...

EXPLORING TRAP1 AS A NOVEL REGULATOR OF MACROPHAGES ASSOCIATED TO MALIGNANT PERIPHERAL NERVE SHEATH TUMORS

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas resistant to conventional therapies and endowed with a poor prognosis. Emerging research has highlighted critical metabolic adaptations of MPNST cells, disclosing the possibility of novel therapeutic approaches. In line with these observations, we have previously demonstrated that MPNSTs are characterized by an enhanced expression of the mitochondrial chaperone TRAP1, which inhibits the enzyme succinate dehydroge...

Assessing the relative role of adenine nucleotide translocator and ATP synthase in the permeability transition

In response to high Ca2+, the inner mitochondrial membrane can undergo a process defined as the permeability transition (PT), that leads to matrix swelling and eventually culminates in cell death initiation. The PT is due to the opening of the PT pore (PTP), a Ca2+-activated and high-conductance channel. Among PTP modulators, thiol reagents (e.g. phenylarsine oxide, PAO) are inducers, while acidic pH acts as inhibitor. The molecular nature of the PTP was highly debated. The adenine nucleotide...

Investigating the roles of F-ATP synthase subunits e and g in Drosophila melanogaster

Differently from yeast and mammals, Drosophila melanogaster does not show a mitochondrial permeability transition (PT), a process caused by the opening of the so-called permeability transition pore (PTP). The PTP is defined as a Ca2+-activated, high-conductance and unselective channel with a maximal conductance of 1.2 nS that allows ions and solutes up to 1.5 kDa to equilibrate across the inner membrane. PTP openings play a role in both Ca2+ homeostasis and cell death initiation. Conversely, ...

Avalanches and oscillations in the brain

Many biological systems present some collective behavior, that turns out not to be dependent on their specific details, and that provides them with some functional advantages, such as a trade-off between robustness (i.e. resilience to perturbation) and flexibility (i. e. responsiveness to environmental stimuli). For example, earthquakes and forest-fires are characterized by a dynamics that is similar to the one of neuronal avalanches that were found in 2003 by Beggs and Plenz. On the other h...

CARATTERIZZAZIONE DEGLI ASPETTI FUNZIONALI DEI DOMINI NON GLOBULARI

This thesis presents my contributions to the field of intrinsically disordered proteins (IDPs) and tandem repeat proteins (TRPs), focusing on resources development and data analysis needed in order to understand their functional aspects. In particular, the first part highlights the importance of visualization tools in understanding the structural and functional aspects of IDPs and TRPs. Visualization tools such as ProseqViewer and FeatureViewer, enable the representation of disorder regions ...

NUOVE PROSPETTIVE NELL'ERA DEI MODULATORI DEL CFTR: APPROCCI EMERGENTI PER IL MONITORAGGIO PRECOCE DELLA MALATTIA POLMONARE IN FIBROSI CISTICA

Background: Improving the early detection and management of cystic fibrosis (CF) lung disease is critical to improving patient outcomes. In addition to traditional methods, non-invasive techniques such as impulse oscillometry (IOS) are gaining traction. The advent of highly effective CFTR modulators, particularly elexacaftor/tezacaftor/ivacaftor (ETI), highlights the need for sensitive markers to monitor treatment effects in broader patient populations. This underscores the importance of expl...

Next Generation Multiple Access Techniques for Wireless Communications

The wireless networks evolution, is marked by diverse and complex use cases. Key categories like massive machine-type communications (mMTC) and ultra-reliable low-latency communications (URLLC) present unique challenges in the internet-of-things (IoT) ecosystem. Concurrently, enhanced mobile broadband (eMBB) applications demand high data rates, especially in densely populated areas. These varying requirements underscore the need for specialized multiple access schemes tailored to each use cas...

Deep Learning approaches for the functional inference of unknown proteins: Argot 3.0

Protein function annotation represents a formidable challenge in modern biology, particularly due to the rapid sequencing of genomes in various species. The process involves assigning specific functions to proteins, especially those newly sequenced and absent from existing biological databases. A comprehensive and accurate database encompassing all proteins and their designated functions holds paramount importance for achieving a nuanced understanding of molecular-level life processes. Such a...

Control and Trajectory Generation Algorithms for high dynamics CNC machines

Nowadays, modern manufacturing relies on high dynamics robots and precise CNC machines to improve production efficiency and machining quality. Unfortunately, those two requirements are frequently at odds with each other. In fact, higher dynamics stress machine components, inducing vibrations that harm machining precision. Thus, meticulous mechanical design and component selection are essential, but cost constraints pose difficulties. However, software methods can enhance machine performances ...

Scopri
Istituto
  • Università degli Studi di Padova7910
Data di pubblicazione
  • 2020 - 20251945
  • 2010 - 20194913
  • 2000 - 20091050
  • 1996 - 19992
Settore disciplinare
  • Settore FIS/05 - Astronomia e Ast...64
  • Settore BIO/11 - Biologia Molecolare47
  • Settore BIO/10 - Biochimica36
  • Settore ING-INF/03 - Telecomunica...36
  • Settore ING-INF/04 - Automatica36
  • Settore M-PSI/01 - Psicologia Gen...34
  • Settore SECS-S/01 - Statistica33
  • Settore INF/01 - Informatica31
  • Settore ING-INF/06 - Bioingegneri...31
  • Settore ING-INF/01 - Elettronica28
Accesso al fulltext
  • open7020
  • embargoed515
  • internalNetwork324
  • no fulltext38
  • partially open13