Promotion of cortico-cerebral precursors expansion by artificial miRNAs against the Emx2 locus

Emx2 encodes for a transcription factor implicated in several aspects of cerebral cortex development, such as morphogenetic field specification, arealization, and lamination. Its overexpression in cortico-cerebral precursors may promote stem cells self-renewal, inhibits their gliogenic commitment, protects neuronal progenitors and stimulates their differentiation, all activities of paramount relevance for purposes of genepromoted brain repair.