Identification of molecules targeting the PKC/ELAV/mRNA cascade as innovative pharmacological tools

Recent literature evidences have been shown that dysregulation of the Protein Kinase C (PKC)/Embrionic Lethal Abnormal Vision (ELAV) proteins pathway led to a significant alteration of the expression of genes codifying for proteins (i.e TNFa, GAP-43, VEGF) primarily involved in several pathologies such as cancer, inflammation and neurodegeneration. Basing on these evidences, the PhD project has been mainly focused on the discovery of new molecules able to modulate the PKC/ELAVs/mRNA cascade, targeting either PKC or ELAV proteins.